DOI: 10.14260/jemds/2015/105 CASE REPORT J of Evolution of Med and Dent Sci/ eISSN- 2278-4802, pISSN- 2278-4748/ Vol. 4/ Issue 04/Jan 12, 2015 Page 724 JESSNERS LYMPHOCYTIC INFILTRATION OF SKIN SUCESSFUL TREATMENT WITH PREDNISOLONE AND HYDROXY CHLOROQUINE P. Guru Prasad 1 , Indira Bonthu 2 , R. Rama 3 , B. T. V. N. Raju 4 , B. Durga Bhavani 5 HOW TO CITE THIS ARTICLE: P. Guru Prasad, Indira Bonthu, R. Rama, B. T. V. N. Raju, B. Durga Bhavani. “Jessners Lymphocytic Infiltration of Skin Sucessful Treatment with Prednisolone and Hydroxy Chloroquine”. Journal of Evolution of Medical and Dental Sciences 2015; Vol. 4, Issue 04, January 12; Page: 724-728, DOI: 10.14260/jemds/2015/105 ABSTRACT: Jessners lymphocytic infiltration of the skin is a chronic, benign T-cell infiltrative disorder, usually manifesting as erythematous papules or plaques on the face, neck and back. we report the case of a 66- year – old man, who presented with erythematous papules and plaques on nose of 4 months duration and erythematous plaque on right arm of 1 month duration. skin biopsy confirmed the diagnosis of jessner’s lymphocytic infiltration of the skin.The evolution was favorable with hydroxy chloroquine and prednisolone. KEYWORDS: Jessners lymphocytic infiltration of skin, hydroxy chloroquine and Prednisolone. INTRODUCTION: Jessner’s lymphocytic infiltration of the skin (JLIS) is a skin condition of unknown aetiology characterized by erythematous papules and plaques located on the head, neck and upper back. The eruption resolves spontaneously after months or a few years but can recur for several years. A variety of empirical treatments has been tried with limited success. Here we report a case of jessners lymphocytic infiltration of skin successfully treated with hydroxychloroquine and prednisolone. CASE REPORT: A 66 Years old man presented with history of erythematous papules and plaques on the nose of 4 months duration and erythematous plaque on right arm of 1 month duration. The present complaint started as small erythematous lesion 0.5 cm size on the right lateral aspect of the nose and gradually involved the bridge & left lateral aspect. There is history of increased erythema and burning sensation on exposure to sunlight. There is no history of oral ulcers, arthralgia. No history of aggravation with intake of spicy foods & alcohol. No history of loss of weight & loss of apetite. No history of similar complaints in the past. No history of diabetes mellitus, hypertension, jaundice & psoriasis. He is a known alcoholic and smoker since 30 years. He is moderately built & moderately nourished, no cyanosis, no clubbing, no jaundice, no generalized lymphadenopathy. Cutaneous examination showed well defined erythematous infiltrated plaque, few erythematous papules at the margins over the nose. well defined erythematous infiltrated plaque of 3x 2 cm2 size on the medial aspect of upper 1/3 rd of the right arm. Oral cavity, nails, palms & soles were normal. Differential diagnosis of tumid DLE, Jessners lymphocytic infiltration of the skin, polymorphic light eruption, sarcoidosis and rosacea (Rhinophyma ) were considered. Haematological investigations, renal, liver & thyroid function tests, borrelia serology, screening for ANA was done.All are with in normal limits.skin biopsy was taken. Histopathological findings showed epidermis is of variable thickness with flattened reteridges, orthokeratosis and increased basal pigmentation.