Accepted Manuscript Computational studies, design and synthesis of Pd(II)-based complexes: Allosteric inhibitors of the Human Topoisomerase-IIα Fillipe V. Rocha, Renan L. Farias, Victor S. Batista, Nailton M. Nascimento-Júnior, Saulo S. Garrido, Andréia M. Leopoldino, Renata N. Goto, Adriano B. Oliveira, Johannes Beck, Christian Landvogt, Antônio E. Mauro, Adelino V.G. Netto PII: S0162-0134(19)30081-9 DOI: https://doi.org/10.1016/j.jinorgbio.2019.110725 Article Number: 110725 Reference: JIB 110725 To appear in: Journal of Inorganic Biochemistry Received date: 8 February 2019 Revised date: 20 May 2019 Accepted date: 27 May 2019 Please cite this article as: F.V. Rocha, R.L. Farias, V.S. Batista, et al., Computational studies, design and synthesis of Pd(II)-based complexes: Allosteric inhibitors of the Human Topoisomerase-IIα, Journal of Inorganic Biochemistry, https://doi.org/10.1016/ j.jinorgbio.2019.110725 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.