Short report Protective properties of Leucas lavendulaefolia extracts against D-galactosamine induced hepatotoxicity in rat J. Kotoky ⁎ , B. Dasgupta, G.K. Sarma Division of Life Sciences, Institute of Advanced Study in Science & Technology Paschim Goragaon, Vigyan Path, Garchuk, Guwahati 781035, Assam, India Received 20 July 2007; accepted 30 November 2007 Available online 9 February 2008 Abstract Different extracts of the leaves of Leucas lavendulaefolia were tested against D-galactosamine (D-GalN) induced liver toxicity in rats. The methanol extract (100 mg/kg, p.o.) which exhibited significant hepatoprotective activity seems to support the claim of folk medicine. © 2008 Elsevier B.V. All rights reserved. Keywords: Leucas lavendulaefolia; Hepatoprotective; D-Galactosamine; Liver ailments 1. Plant Leucas lavendulaefolia Rees (syn. L. linifolia Spreng) (Lamiaceae) collected locally in the Khanapara area of Guwahati (State of Assam) in 2002–03 was identified by Dr. G. Sarma, Botany Department, Gauhati University, Guwahati, Assam. A voucher specimen (No. JK-02/95) is deposited in the Life Sciences Division, Institute of Advanced Study in Science & Technology. 2. Use in the traditional medicine The leaves of the plant have a bad taste, and are used as expectorant, carminative, stomachic, laxative, vermifuge, [1,2] and in jaundice [3], migraine [4], as febrifuge, in loss of appetite, snake bite, chronic rheumatism [5,6]. It is reported to be used as anthelmintic, tonic, and in piles, sore ears and seeds are aphrodisiac (Yunani) [2], antipyretic [7], and have anti-inflammatory and wound healing properties [8]. 3. Previously isolated constituents Essential oil, alkaloid, fatty alcohol [9], acacetin, chrysoeriol, linifolioside, linifoliol [10–12]. Fitoterapia 79 (2008) 290 – 292 www.elsevier.com/locate/fitote ⁎ Corresponding author. Tel.: +91 361 2740679; fax: +91 361 2740659. E-mail address: jkotoky@yahoo.com (J. Kotoky). 0367-326X/$ - see front matter © 2008 Elsevier B.V. All rights reserved. doi:10.1016/j.fitote.2007.11.026