Revista de Chimie https://revistadechimie.ro https://doi.org/10.37358/Rev. Chim.1949 Rev. Chim., 71 (7), 2020, 504-512 504 https://doi.org/10.37358/RC.20.7.8270 The Impact of Complex Treatment, Doxorubicin C 27 H 29 NO 11 , Bleomycin C 55 H 84 N 17 O 21 S 3 , Vinblastine C 46 H 58 N 4 O 9 and Dacarbazine C 6 H 10 N 6 O Correlated with Haematological Parameters on Hodgkin’s Lymphoma Survival Prognostic MONICA PESCARU 1 , CRISTINA POTRE-ONCU 1* , ADINA – IOANA BUCUR 2 , BOGDAN NICULESCU 3 , STELA IURCIUC 4* , VIRGIL RADU ENATESCU 5 , HORTENSIA IONITA 1 , MADALINA VERONICA BORUGA 6 , OVIDIU POTRE-ONCU 1 1 University of Medicine and Pharmacy „Victor Babes” from Timisoara, Hematology Department, 2 Eftimie Murgu Sq., 300041, Timisoara, Romania 2 University of Medicine and Pharmacy „Victor Babes” Timisoara, Public Health and Health Management Department , 2 Eftimie Murgu Sq., 300041 Timisoara, Romania 3 University Constantin Brancusi, 30 Calea Eroilor, 210135, Targu Jiu, Romania 4 Victor Babes University of Medicine and Pharmacy, Department of Cardiology, Discipline of Ambulatory Internal Medicine, Cardiovascular Prevention and Rehabilitation, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania 5 University of Medicine and Pharmacy „Victor Babes” from Timisoara, Psychıatry Department, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania 6 University of Medicine and Pharmacy „Victor Babes” Timisoara, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania Abstract: Many prognostic factors for HL have been proposed in the past and some of these were included in several prognostic scores. Tumor stage and spread, age, gender and various biological parameters are considered to have an effect on disease evolution, with the prognostic scores stratifying patients into risk groups and guiding the course of treatment. In the present study we have enrolled 54 patients with Hodgkin’s lymphoma admitted in the Hematology Department within the City Emergency Clinical Hospital Timisoara over a 4-year period. We aimed to see if a statistically significant correlation can be made between hemoglobin, white blood cell, lymphocyte, eosinophil, monocyte and platelet levels at the time of diagnosis on the one hand, and response to treatment and patients’ survival, on the other hand. Patients’ response to treatment was evaluated according to Cheson criteria, with best response to the combination of ABVD(doxorubicin C27H29NO11, bleomycin C55H84N17O21S3, vinblastine C46H58N4O9, dacarbazine C6H10N6O) and radiation therapy. Response to treatment was also influenced by eosinophil levels at diagnosis and this has effects on survival. Finally, lymphocyte and platelet levels at diagnosis correlated with survival times in our study group. Therefore, eosinophil, lymphocyte and platelet levels at diagnosis could be considered as prognostic factors for HL, although further studies are needed to validate our findings. Keywords: Hodgkin lymphoma, treatment, prognostic factors 1.Introduction Hodgkin’s lymphoma (HL) is among the most treatable malignancies, over 80% of the patients undergoing a therapy regimen being cured; conversely, left untreated, 90% of patients will die in up to 3 years [1]. Indeed, prognosis of HL has been significantly improved over the past decades by using effective chemotherapy regimens based on the individual risk of patients [2]. Identification of risk factors is therefore critical for providing tailored treatment strategies, while both clinical and biological parameters were utilized as prognostic factors for HL and are widely included in the prognostic scores to discriminate between risk groups [3]. *email: cris24sorica@gmail.com,, stela_iurciuc@yahoo.com All authors have equal contributions