P e m b r o l i z u m a b , N i v o l u m a b a n d I p i l i m u m a b i s a s s o c i a t e d w i t h A n t e r i o r S e g m e n t , P o s t e r i o r S e g m e n t a n d N e u r o - O p h t h a l m i c C o m p l i c a t i o n s : A S y s t e m a t i c R e v i e w . S a m p a n a F a t i m a 1 , M u h a m a d A b r a r 2 , R o h a m a Q u b r a 3 , D e l i m a M a r i a 3 , R a s h i d M a h m o o d k h a n 3 , N a s m a W a b a s a 3 C o r r e s p o n d e n c e : D r . S a m p a n a F a t i m a D e p a r t m e n t o f P h y s i o l o g y 1 S h a l a m a r M e d i c a l a n d D e n t a l C o l l e g e , L a h o r e , P a k i s t a n . E m a i l i d : s a m p a n a s a m i @ g m a i l . c o m 2 N a t i o n a l U n i v e r s i t y o f S c i e n c e a n d T e c h n o l o g y , P a k i s t a n 3 B a h a w a l V i c t o r i a H o s p i t a l , B a h a w a l p u r , P a k i s t a n A b s t r a c t : I n t r o d u c t i o n : Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that deactivate inhibitory receptors of immune system and restore the antitumor immunity. 2 ICIs provides novel alternative treatment for high prevalence cancers like, melanoma, lung cancer, lymphoma, metastatic prostate carcinoma and renal tumors. M e t h o d o l o g y : Systemic review was conducted according to the Cochrane handbook of systemic reviews and ophthalmology book of systemic reviews and reported based on PRISMA. Articles from August 2017-August 2022.Total 57 articles were obtained. Out of which only 25 were selected discussing Ophthalmic ICIs related adverse effects in previously normal patients. R e s u l t s : Ipilimumab is commonly observed in inducing optic neuropathy, anterior uveitis, and graves ophthalmopathy in previously normal patient. Anterior uveitis and pan uveitis, ocular hypotony and complete visual loss were most reported with pembrolizumab. Most common ocular complications associated with Nivolumab is uveitis. Degree of uveitis and its presentation varied in different cases. C o n c l u s i o n : ICI’s are frequently associated with neuro-ophthalmic complications, though reversibility