|| ISSN(online): 2589-8698 || ISSN(print): 2589-868X || International Journal of Medical and Biomedical Studies Available Online at www.ijmbs.info NLM (National Library of Medicine ID: 101738825) Index Copernicus Value 2021: 70.61 Research Article Volume 7, Issue 5; May : 2023; Page No. 01-03 1 | Page To Compare the Rescue Analgesia used in Post-Operative Period of Dexmedetomidine and Clonidine as an Adjuvant to Intrathecal Bupivacaine in Patients Undergoing Total Abdominal Hysterectomy Dr. Rupesh Choudhary 1 , Dr. Rahul Sharma 2 , Dr. Ankita Jamwal 3 , Dr. Divya Drishti 4 1 Junior Resident, Dept. of Anaesthesia, Indira Gandhi Medical College & Hospital, Shimla. 2 Junior Resident, Dept. of Anaesthesia, Indira Gandhi Medical College & Hospital, Shimla. 3 Senior Resident, Dept. of Obstetrics & Gynaecology, Shri Lal Bahadur Shastri Government Medical College & Hospital, Mandi 4 Medical Office, PHC Pharer, Kangra Received: 13-02-2023 / Revised: 27-02-2023 / Accepted: 20-03-2023 DOI: https://doi.org/10.32553/ijmbs.v7i5.2706 Corresponding author: Dr. Ankita Jamwal Conflict of interest: No conflict of interest. Abstract Background: Spinal block is the first choice for lower abdominal surgeries. Bupivacaine is the most common local anaesthetic used but has a shorter duration of action. Many adjuvants have been used to improve the quality of analgesia till postoperative period. In this study, we used α2-agonists. Methods: A prospective randomized single blind study was conducted in the Department of Anaesthesia IGMC SHIMLA at Kamla Nehru state hospital. Results: Injection PCM 1gm was used as rescue analgesic if VAS ≥4 was achieved in any patient. In Group C 10 patients received Inj PCM as compared to 8 patients in Group D. One patient in each group received 1 dose, 5 in Group C and 2 in Group D received 2 doses and 4 in Group C and 5 in Group D received 3 doses of Inj PCM in 24 hrs postoperative period. (p=0.693). Conclusion: We concluded that the rescue Analgesia used in post operative period. Keywords: Dexmedetomidine, Clonidine, Bupivacaine, Rescue Analgesia Introduction Hysterectomy is the most frequently performed gynecologic surgical procedure. It has a broad spectrum of indications ranging from benign tumours to malignant gynecological diseases. Hysterectomy is most often indicated when medical treatment or less invasive methods have failed 1 . Abdominal hysterectomy is often a long duration procedure and warrants intense pain relief in the peri and post-operative period. Among various type of regional anaesthesia single shot spinal anaesthesia is still the first choice for lower abdominal / lower limb surgery because of its rapid onset, superior blockade, lower risk of infections, lesser failure rate and cost effectiveness. It blunts the stress response to surgery and decreases the incidence of postoperative thromboembolic events. It also provides rapid and adequate surgical anaesthesia, early ambulation after surgery and the ability to void enables the patient fit for discharge early 2, 3 . Major drawback of single shot spinal anaesthesia is its short duration of block and lack of postoperative analgesia. Due to this intrathecal adjuvant have gained popularity which aim at prolonging duration of block, better success rate and fast postoperative recovery. Local anaesthetic, bupivacaine, is the most common agent used for spinal anaesthesia but has