IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN:2278-3008, p-ISSN:2319-7676. Volume 11, Issue 6 Ver. VI (Nov. - Dec.2016), PP 29-32 www.iosrjournals.org DOI: 10.9790/3008-1106062932 www.iosrjournals.org 29 | Page Comparative Study of Synergic Effects of Spasmo Proxyvon with Some food Items. Ksh.Mona Devi, A.K. Gupta, S.Joychandra, Munish Mishra Department of Forensic Science, SHIATS Abstract: Spasmo proxyvon tablet is a popular antispasmodic drug and is covered under Narcotic Drugs. It is increasingly being abused for its opoid effect due to easily available. Recently, it has been being made cocktail with different food product to get stronger its effect. The present study was aimed to evaluate the type of food/beverage being use as cocktail with S.P.drug. In this study, tea, coffee, sweets and cigarette have been taken as enhancer of S.P drugs and Survey data were taken from 150 drug addicted volunteers.97 drugs abuser consumed tea,9 drug abuser use coffee. Sweets as cocktail using drug abusers were 6 in number.14 drug abusers used cigarettes as drug enhancer. Numbers of drug abusers who used combination food items i.e. Tea and sweets, tea and cigarettes, coffee and cigarettes, sweets and cigarettes as drugs affect enhancer are 8, 11, 3, 2 respectively. Percentage of number of persons who used tea, coffee, sweets, cigarettes, tea & cigarettes, coffee & cigarettes, sweets & cigarettes as cocktail with drug Spasmo proxyvon were 64.67% ,6%,4%,9.33%,5.33%,7.33%,2% and 1.33% respectively. Consuming of tea as cocktail was strongest effect of drug. Biochemistry of this drug inside our body in this area is needed to be investigated. Keyword: Spasmo Proxyvon, Dextropropoxyphene, Caffeine, Tea I. Introduction Spasmo-Proxyvon is a popular antispasmodic drug fromWockhardt that is increasingly being abused of late. These drugs are covered by the Narcotic Drugs and Psychotropic Substances Act; there has been a recent trend towards abuse of pharmaceutical agentssuch as pentazocine, propoxyphene and buprenorphine. It contains paracetamol (acetami-nophen), dicyclomine, and dextropropoxyphene. This combined drug formulation sold as gelatin capsules is easily available, and is increasingly being abused for its opioid effect. Composition of Spasmo Proxyvon API Quantity Quantity Acetaminophen 400 mg 400 mg Dextropropoxyphene 65mg 65 mg Dicyclomine (Dicycloverine) 10mg 10 mg Dextropropoxyphene is classified as an opioid analgesic and is used to treat mild to moderate pain. It can be used to ease pain before, during and after an operation. It is often combined with Acetaminophen and sold in several countries (note: In some countries, compounds containing Dextropropoxyphene are available only with a valid doctor's prescription). Dextropropoxyphene is derived from a much stronger opiate agonist called Methadone. It is approximately 1/2 to 2/3 as potent as Codeine. In the United States, Dextropropoxyphene HCI is available as a prescription with Acetaminophen in ratio anywhere from 30 mg/600 mg to 60 mg, 325.Mg respectively. These are usually named "Darvocet," "Darvin," or "Darvon." In Australia, dextropoxyphene is available on prescription, both as a combined product (32.5 mg dextropropoxyphene per 325 mg acetaminophen) known as either "Di-gesic", "Capadex", or "Paradex" and in pure form (100 mg capsules) known as "Doloxene". Dextropropoxyphene is marketed in Europe as "Abalgin" amongst other names. The maximum doses for the constituents of Spasmo Proxyvon (constituents shown above) are as follows: Acetaminophen: 2-4 grams/day Dextropropoxyphene HCI: 390 mg/day Dextropropoxyphene Napsylate: 600 mg/day Dicyclomine: No available safety data for dose above 80 mg/day Dextropropoxyphene (DPP) has a 1/2 life of 6 to 12 hours. However, its metabolite, norpropoxyphene (NPP) has a 1/2 life of 30 to 36 hours. After oral ingestion, onset of effects is usually 1 hour, with peak plasma concentrations achieved within 2 - 21/2 hours. Repeated doses (at intervals of 6 hrs.), lead to increasing in plasma concentrations, eventually reaching a plateau at/after the 9th dose (at 48 hrs.). It is worth knowing that due to extensive first-pass metabolism of DPP, the plasma concentrations after a single dose may be four times lower than those found in steady state (achieved with regular dosing at 6 hr. intervals). Also, with repeated dosing, it takes longer for the metabolite to be eliminated. On the whole, the metabolism of DPP takes a lot