Journal Pre-proofs Synthesis and highly potent anti-inflammatory activity of licofelone- and ke- torolac-based 1-arylpyrrolizin-3-ones Damian A. Madrigal, Carlos H. Escalante, Gabriel A. Gutiérrez-Rebolledo, José M. Cristobal-Luna, Omar Gómez-García, Roberto I. Hernández-Benitez, Ana L. Esquivel-Campos, Salud Pérez-Gutiérrez, Germán A. Chamorro- Cevallos, Francisco Delgado, Joaquín Tamariz PII: S0968-0896(19)30503-6 DOI: https://doi.org/10.1016/j.bmc.2019.115053 Reference: BMC 115053 To appear in: Bioorganic & Medicinal Chemistry Received Date: 28 March 2019 Revised Date: 18 August 2019 Accepted Date: 19 August 2019 Please cite this article as: Madrigal, D.A., Escalante, C.H., Gutiérrez-Rebolledo, G.A., Cristobal-Luna, J.M., Gómez-García, O., Hernández-Benitez, R.I., Esquivel-Campos, A.L., Pérez-Gutiérrez, S., Chamorro-Cevallos, G.A., Delgado, F., Tamariz, J., Synthesis and highly potent anti-inflammatory activity of licofelone- and ketorolac- based 1-arylpyrrolizin-3-ones, Bioorganic & Medicinal Chemistry (2019), doi: https://doi.org/10.1016/j.bmc. 2019.115053 This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2019 Published by Elsevier Ltd.