Ind. J. Pharm. Edu. Res, 2023; 57(2):503-510. https://www.ijper.org Original Article Indian Journal of Pharmaceutical Education and Research, Vol 57, Issue 2, Apr-Jun, 2023 503 DOI: 10.5530/ijper.57.2.61 Copyright Information : Copyright Author (s) 2023 Distributed under Creative Commons CC-BY 4.0 Publishing Partner : EManuscript Tech. [www.emanuscript.in] Caryota urens and Hyophorbe lagenicaulis as Nutraceutical by Managing Commercially Available Drug Induced Nephrotoxicity Saumya Das*, Richa Shakya, Avijit Mazumder, Anamaika Gautam Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, Uttar Pradesh, INDIA. ABSTRACT Background: Caryota urens fowers and Hyophorbe lagenicaulis leaves have huge benefcial properties, medicinal uses and rich phyto-pharmacological constituents. Nutraceutical potentiality of the selected plants on the basis of phytochemicals present in the aerial parts of Caryota urens and Hyophorbe lagenicaulis were taken as the background of the study. Aim: The present study investigates the nephroprotective potentiality of Caryota urens fowers and Hyophorbe lagenicaulis leaves against cisplatin and gentamycin induced nephrotoxicity. Materials and Methods: The extract of Caryota urens fowers and Hyophorbe lagenicaulis leaves were screened for preliminary phytochemical analysis. The in vitro antioxidant activity of Caryota urens fower extract (CUFE) and Hyophorbe lagenicaulis leaves extract (HLLE) was performed by DPPH and H 2 O 2 radical scavenging activity. In vivo acute oral toxicity test was performed by following OECD guideline 420. The screening models for cisplatin and gentamycin induced nephrotoxicity by using albino Wistar rats were also carried out. Results: In in vitro antioxidant studies CUFE and HLLE (*p<0.01 and **p<0.001) for both standard and test drugs. It also act as potent nutraceuticals in cisplatin and gentamycin induced nephrotoxicity (**p<0.001). No major side efects were seen in any of the experimental animal during acute oral toxicity. Conclusion: CUFE and HLLE (1:1) have nutritionally rich source of dietary food supplements and due to this they are also helpful in managing the commercial drugs induced nephrotoxicity. Keywords: Nutraceuticals, Phytochemical, Cisplatin, Gentamycin, Nephrotoxicity. INTRODUCTION Nutraceuticals are dietary components naturally found in foods and believed to have a health beneft, including protecting and treating from many chronic diseases. Nutraceutical provides a better immune system. 1 An especially increasing nutritional interest in promoting healthiness. Current therapies have increased the life span of many peoples and these medicines are helpful in managing several diseases. For health care benefts completely understands the mechanism of action of major nutraceuticals food supplements and their possible efcacy in anti-aging and to improve RBC level, VLDL level, and with other health care benefts. 2 Discoveries gave us prompts to continue for useful food advancement having nutraceutical potential. 3 Te possible mechanisms of their activity, evidence for potential health promoting activity, antioxidants and these phytochemicals in nutrition as substitutes for synthetic antibiotic activity promoters has also been addressed. 4,5 Caryota urens (family: Arecaceae) is widely known as the fsh tail palm. Te palm tree as a whole is native to Sri Lanka, India, Myanmar, and Malaysia, where it flls up felds and jungle clearings. 6 It is said to have originated in Cambodia. Urens is Latin for "stinging," and refers to the compounds found in Caryota urens fruit. Solitary fshtail palm, kitul palm, toddy palm, wine palm, sago palm, and jaggery palm are some of the common names in English. 7,8 Te promising cancer prevention by Caryota urens and α-glucosidase restraint these herbal extracts are supposed to most likely because of the presence of bioactive phyto-pharmaceuticals present in them which acts as a potent nutraceutical elements. 9,10 Hyophorbe lagenicaulis (family Arecaceae) commonly known as bottle palm or palmistegargoulette, is a species of fowering plant. It is native to Round Island, Mauritius. 11,12 Inspite of efective role of Caryota urens and Hyophorbe lagenicaulis in folk traditional medicines, till date not appropriate scientifc evidences are available on their biological activities and phytochemical distribution. 13,14 Both the selected plants are nutritionally rich therapeutic values and contains a combination of flavonoids, carotenoids, phenolics, phytoestrogenes and saturated fatty acids and sugars like sucrose, Received: 13-08-2022; Revised: 28-11-2022; Accepted: 20-01-2023. Correspondence: Saumya Das Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, Uttar Pradesh, INDIA. Email id: awasthi.saumya22@gmail.com