Open Journal of Obstetrics and Gynecology, 2023, 13, 825-836 https://www.scirp.org/journal/ojog ISSN Online: 2160-8806 ISSN Print: 2160-8792 DOI: 10.4236/ojog.2023.135071 May 25, 2023 825 Open Journal of Obstetrics and Gynecology Gestational TSH Levels and Their Association with Obstetric and Neonatal Outcomes in Lebanon: A National Observational Retrospective Study Georges Abi Tayeh * , Wael Abdallah, Yara AbdelKhalek, Serge Sassine, Hoda Zakaria Department of Obstetrics and Gynecology, Hôtel-Dieu de France University Hospital, Beirut, Lebanon Abstract Objectives: Gestational hypothyroidism is associated with obstetric compli- cations and disturbances in the offspring development; however, it remains easy to treat. The objective of the study was to describe thyroid-stimulating hormone (TSH) levels in pregnant women and analyze their association with pregnancy course and outcome. Design: This national, observational, retros- pective study analyzed data on Lebanese pregnant women visiting their ob- stetrician as part of their routine follow up. Participants, Setting and Me- thods: Enrolled subjects were all pregnant women who visited the obstetrics clinic from 01 September 2017 until 31 August 2018, as part of their routine follow up and have a TSH level record. In 2020, during their routine fol- low-up visit, the participants signed an informed consent to allow the inves- tigator to access the data retrospectively and enter them into his database. Relevant participant characteristics and outcome data were collected from clinic files of the private clinic of Dr Abi Tayeh, at the Department of Obste- trics and Gynecology, Hôtel-Dieu de France University Hospital, Beirut, Lebanon. Results: A total of 419 women were enrolled, 11.5% of them re- ported at least one comorbidity prior to pregnancy, most often the antiphos- pholipid syndrome, followed by thrombophilia and hypothyroidism. At least one complication was reported for 18.4% of participants. Around 87.6% of participants delivered a full-term baby with normal birth weight for most. The average TSH value for all participants was within the normal range at all time-points. Highest TSH values were recorded during the first trimester. As treatment was immediately initiated in women with abnormal TSH levels, no correlation was observed between TSH levels and pregnancy outcomes or How to cite this paper: Tayeh, G.A., Ab- dallah, W., AbdelKhalek, Y., Sassine, S. and Zakaria, H. (2023) Gestational TSH Levels and Their Association with Obstetric and Neonatal Outcomes in Lebanon: A Nation- al Observational Retrospective Study. Open Journal of Obstetrics and Gynecology, 13, 825-836. https://doi.org/10.4236/ojog.2023.135071 Received: April 7, 2023 Accepted: May 22, 2023 Published: May 25, 2023 Copyright © 2023 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access