Comparative clinical outcomes of Taiwanese patients with resected buccal and tongue squamous cell carcinomas Chun-Ta Liao a,1 , Yu-Wen Wen b,1 , Lan Yan Yang c,1 , Shu Ru Lee b , Shu-Hang Ng d , Tsang-Wu Liu e , Sen-Tien Tsai f , Ming-Hsui Tsai g , Jin-Ching Lin h , Peir-Rong Chen i , Pei-Jen Lou j , Cheng Ping Wang j , Pen-Yuan Chu k , Tzer-Zen Hwang l , Yi-Shing Leu m , Kuo-Yang Tsai n , Shyuang-Der Terng o , Tsung-Ming Chen p , Cheng-Hsu Wang q , Chih-Yen Chien r , Wen-Cheng Chen s , Li-Yu Lee t , Chien-Yu Lin u , Hung-Ming Wang v , Chia-Hsun Hsieh v , Chung-Kan Tsao w , Tuan-Jen Fang a , Shiang-Fu Huang a , Chung-Jan Kang a , Kai-Ping Chang a , Tzu-Chen Yen x,⇑ a Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan b Clinical Informatics and Medical Statistics Research Center, Chang Gung University, Taoyuan, Taiwan c Biostatistics and Informatics Unit, Clinical Trial Center, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan d Department of Diagnostic Radiology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan e National Institute of Cancer Research, National Health Research Institutes, Taiwan f Department of Otolaryngology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Taiwan g Department of Otorhinolaryngology, Head and Neck Surgery, China Medical University Hospital, Taiwan h Department of Radiation Oncology, Taichung Veterans General Hospital, Taichung, Taiwan i Department of Otolaryngology, Hualien Tzu Chi Hospital and Tzu Chi University, Hualien, Taiwan j Department of Otolaryngology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan k Department of Otolaryngology, Taipei Veterans General Hospital, Taipei, Taiwan l Department of Otolaryngology, E-DA Hospital and I-Shou University, Kaohsiung, Taiwan m Department of Otolaryngology, Mackay Memorial Hospital, Taipei, Taiwan n Department of Oral and Maxillofacial Surgery, Head and Neck Surgery, Changhua Christian Hospital, Changhua, Taiwan o Department of Head and Neck Surgery, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan p Department of Otolaryngology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan q Division of Hematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan r Department of Otolaryngology, Chang Gung Memorial Hospital – Kaohsiung Medical Center, Chang Gung University College of Medicine, Taiwan s Department of Radiation Oncology, Chang Gung Memorial Hospital, Chiayi, Taiwan t Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan u Department of Radiation Oncology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan v Department of Medical Oncology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan w Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan x Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan article info Article history: Received 2 December 2016 Received in revised form 26 January 2017 Accepted 12 February 2017 Keywords: Squamous cell carcinoma Buccal mucosa Tongue Prognosis Cancer Registry abstract Objectives: Although patients with buccal squamous cell carcinoma (SCC) usually show acceptable out- comes, local control and survival rates are generally lower than those observed for tongue SCC. This study was designed to compare the clinical outcomes of Taiwanese patients with these two common oral cavity malignancies. Methods: Patients with first primary buccal or tongue SCC who were included in the Taiwanese Cancer Registry Database between 2004 and 2012 were eligible. The study sample consisted of 16,379 patients (7870 buccal SCC and 8509 tongue SCC) who received surgery with or without adjuvant therapy. The 5- year disease-specific survival (DSS) and overall survival (OS) rates served as the outcome measures. Results: Compared with tongue SCC, patients with buccal SCC had a higher prevalence of males (95.7% vs. 86.4%, p < 0.0001), pT4 disease (21.4% vs. 12.7%, p < 0.0001), and p-Stage IV (30.4% vs. 24.8%, p < 0.0001) but a lower frequency of pN2 disease (15.2% vs. 18.5%, p < 0.0001). The 5-year DSS and OS rates of buccal SCC patients were slightly higher than those of tongue SCC (78% vs. 77%, p = 0.0297; and 71% vs. 69%, http://dx.doi.org/10.1016/j.oraloncology.2017.02.011 1368-8375/Ó 2017 Elsevier Ltd. All rights reserved. ⇑ Corresponding author at: Department of Nuclear Medicine, Chang Gung Memorial Hospital at Linkou, No. 5, Fu-Hsing St., Kwei-Shan, Taoyuan, Taiwan. E-mail address: yentc1110@gmail.com (T.-C. Yen). 1 Chun-Ta Liao, Yu-Wen Wen, and Lan Yan Yang contributed equally to this work. Oral Oncology 67 (2017) 95–102 Contents lists available at ScienceDirect Oral Oncology journal homepage: www.elsevier.com/locate/oraloncology