Open Journal of Epidemiology, 2021, 11, 267-277 https://www.scirp.org/journal/ojepi ISSN Online: 2165-7467 ISSN Print: 2165-7459 DOI: 10.4236/ojepi.2021.113023 Jul. 30, 2021 267 Open Journal of Epidemiology Lipid Accumulation Product: Reliable Marker for Cardiovascular Risk Detection? Lidiane Aparecida Vila Pires 1 , Ricardo José Tofano 1,2,3 , Sandra Maria Barbalho 1,2,4,5* , Claudia Rucco Penteado Detregiachi 1,2,5 , Marcelo Dib Bechara 1 , Viviane Alessandra Capelluppi Tofano 1 , Jesselina Francisco dos Santos Haber 1,5 , Eduardo Federighi Baisi Chagas 2,5 , Ana Maria Gonçalvez Milla 2 , Karina Quesada 1 1 School of Medicine, University of Marília (UNIMAR), Marília, São Paulo, Brazil 2 Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), São Paulo, Brazil 3 Cardiology Unit of the UNIMAR Beneficent Hospital (HBU), Marilia, São Paulo, Brazil 4 Department of Biochemistry and Nutrition, Faculty of Food Technology of Marília, Marília, São Paulo, Brazil 5 CENID (Interdisciplinary Center on Diabetes)—UNIMAR—Marília, São Paulo, Brazil Abstract The Lipid Accumulation Product (LAP) is a clinical marker of visceral obesity and has been proposed as a simple, inexpensive, and accurate tool to estimate cardiovascular risk and mortality. The aim of this study was to verify the as- sociation of LAP with anthropometric, biochemical, visceral adiposity index and IR in adults and the elderly. This single cross-section center clinical study, with experimental, analytical, primary, and observational design, in- cluded 210 participants. Anthropometric (Body Mass Index (BMI), Waist Circumference (WC), and Neck Circumference (NC)), LAP, Visceral Adipose Index (VAI), and biochemical parameters (fasting glycemia, insulinemia (to calculate the Homa-IR index), total cholesterol, LDL-c, HDL-c, and triglyce- rides) were evaluated. The results showed that by separating the sample into three groups (adequate BMI and WC, adequate BMI and elevated WC, and elevated BMI and WC), the group with high BMI and WC showed a high value of LAP and VAI compared to the other groups, with a significant dif- ference. Still, the data show a positive and significant correlation when relat- ing the LAP with VAI, HOMA-IR, BMI, WC, NC, total cholesterol, triglyce- rides, and Diastolic Blood Pressure. It also showed an inversely proportional relationship when associating LAP with HDL-c (p < 0.0001). Thus, we show that LAP is closely related to visceral adiposity, IR, altered lipid parameters, and blood pressure, especially diastolic in the patients included in our study. For these reasons, we suggest that LAP is a reliable indicator of promising visceral adiposity for early detection of cardiovascular risk in the adult and senior population. How to cite this paper: Pires, L.A.V., Tofano, R.J., Barbalho, S.M., Detregiachi, C.R.P., Bechara, M.D., Tofano, V.A.C., Haber, J.F. dos S., Chagas, E.F.B., Milla, A.M.G. and Quesada, K. (2021) Lipid Ac- cumulation Product: Reliable Marker for Cardiovascular Risk Detection?. Open Jour- nal of Epidemiology, 11, 267-277. https://doi.org/10.4236/ojepi.2021.113023 Received: April 20, 2021 Accepted: July 27, 2021 Published: July 30, 2021 Copyright © 2021 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access