Original Article Bleeding from the upper gastrointestinal tract is a communal symptom in medical institutions and gastroenterology clinics [1]. It has multiple causes that varies greatly in different geographic regions of the world [2]. Despite developments in treatment, upper gastrointestinal bleeding secondary to peptic ulcer remains a serious medical risk with signiïcant mortality, morbidity and healthcare costs. The peptic ulcer disease is assumed to be reduced due to improvements in endoscopic techniques, decreased Helicobacter pylori DOI: https://doi.org/10.54393/pjhs.v3i06.308 Fahim M et al., Frequency of Bleeding Duodenal Ulcer in Patients presenting with Upper Gastrointestinal Bleeding 1 2 3 4* 2 Muhammad Fahim , Muhammad Sohail , Muhammad Sajjad Khan , Fahim Ullah Khan , Salman ur Rashid , Shakeel 5 Akhter ¹MTI, Mardan Medical Complex, Mardan, Pakistan ²Primary Health Services Mardan, Pakistan ³Primary Health Services Bannu, Pakistan ⁴Primary Health Services D.I.Khan, Pakistan ⁵MTI, Bacha Khan Medical Complex Swabi, Pakistan  incidence and an increased use of acid-inhibiting drugs. However, advances in peptic ulcer treatment have not necessarily reduced the number of hospitalizations for upper gastrointestinal bleeding following peptic ulcer disease or the risk of adverse events, counting mortality. Conðicts in previous studies results can be clariïed by various factors. Gastric ulcer epidemiology has evolved and is no longer driven by H. pylori. An aging population has increased use of non-steroidal anti-inðammatory drugs (NSAIDs), counting aspirin. This results in more frequent Frequency of Duodenal Ulcer in patients with Gastrointestinal Bleeding INTRODUCTION Acute upper gastrointestinal bleeding is a well-known complication of peptic ulcers and erosions. The prevalence of Upper Gastrointestinal bleeding ranges from 48-160 patients per 100,000 people, with consistent reports of higher incidence among elderly and men. Objective: To determine the incidence of duodenal ulcer bleeding in patients admitted to the tertiary care hospital with bleeding from the upper gastrointestinal tract. Methods: The study included 270 patients, 20 to 70 years of age, of both sexes with upper gastrointestinal bleeding within 24 hours of symptom onset. A detailed interview and complete physical examination were performed. Endoscopic examination protocols were followed and accomplished within 48-hrs of the start of symptoms as bleeding. All of the above information, including age, sex and duodenal ulcer, was documented in a formerly designed proforma. The data were analyzed and entered in SPSS 22.0. Results: The mean age and SD were 54.5 + 10.54. 110 (40.74%) patients were 20-45 years old and 160 (59.25%) subjects were 46-70 years old. 190 (70.37%) patients were male and 80 (29.62%) females. While in this study duodenal ulcer was seen in 64 (23.70%) patients, 206 (76.29%) patients did not have duodenal ulcer. Conclusions: Upper Gastrointestinal bleeding is secondary to duodenal ulcers due to an increase in early readmissions over time, as observed in this local population, resulting in a higher incidence of duodenal ulcers in our local population. A R T I C L E I N F O ABSTRACT How to Cite: Fahim, M. ., Sohail, M. ., Sajjad Khan, M., Khan, F. U. ., Ur Rashid, S. ., & Akhter, S. . (2022). Frequency of Bleeding Duodenal Ulcer in Patients Presenting with Upper Gastrointestinal Bleeding: Frequency of Duodenal Ulcer in patients with Gastrointestinal Bleeding. Pakistan Journal of Health Sciences, 3(06). https://doi.org/10.54393/pjhs.v3i06.308 Key Words: Gastrointestinal surgery, Peptic ulcer bleeding, Endoscopy and Mortality *Corresponding Author: Fahim Ullah Khan Primary Health Services, D.I.Khan, Pakistan fahimkhan757@gmail.com Received Date: 31th October, 2022 th Acceptance Date: 15 November, 2022 th Published Date: 30 November, 2022 PAKISTAN JOURNAL OF HEALTH SCIENCES https://thejas.com.pk/index.php/pjhs Volume 3, Issue 6 (November 2022) PJHS VOL. 3 Issue. 6 November 2022 Copyright © 2022. PJHS, Published by Crosslinks International Publishers 88