NE US Academic Publishers Advances in Animal and Veterinary Sciences November 2018 | Volume 6 | Issue 11 | Page 492 INTRODUCTION R ecently, there has been a sharp increase in the vol- ume of accumulation of pollutants in the environ- ment, the composition and properties of which are very diverse. In the gold mining and processing areas as well as in the chemical industry, the main pollutants are heavy metals. In agricultural production, soil contamination with heavy metals is associated with the use of fertilizers and pesticides (Granero and Domingo, 2002; Cao et al., 2010; Tongesayi et al., 2013). Heavy metals are found everywhere as a result of natu- ral processes and anthropogenic infuences. Te level of natural heavy metals is relatively low. Te concentration of heavy metals increases due to anthropogenic infuenc- es such as mining, irrigation, pesticide use and chemical fertilizers (Granero and Domingo, 2002; Cao et al., 2010; Tongesayi et al., 2013). Environmental contamination can also occur due to metal corrosion, atmospheric deposition, metal ion erosion and heavy metal leaching, as well as the re-suspension of sediment and the evaporation of metals from water resources into soil and groundwater (Nriagu, 1989). In addition, the intensive construction of urban and rural infrastructure, the increase in the number of vehi- cles and general lifestyle changes, especially in develop- ing countries, exacerbated the problem by increasing the point sources of metal emissions. Because of their preva- lence, toxicity and persistence, heavy metals are of particu- lar concern in any ecological system. Te real problem is that the accumulation of heavy metals in urban soils, sed- iments, road dust and water bodies should be considered Research Article Abstract | Te accelerated growth rates of cities, industrial development and mineral extraction have led to an increase in the volume of heavy metals entering the environment. Te impact of heavy metals has been studied by many scientists, but there are still limited data on the complex efect of various heavy metals. Terefore, currently, there is an increasing interest in the efect of several heavy metals on living organisms. In this research, we modeled the chronic efects of three groups of heavy metals on the body of rats, as well as determined their biochemical parameters and changes in comparison with the control group. Te results of our studies have shown that when combined with chronic intoxication with heavy metal salts, the biochemical indices of blood may vary, which is caused by a violation of the functions of the liver, kidneys, and heart muscle. Against the background of the toxic efects of heavy metals, we used “Ursodex” and “Schrot Rastoropshy” as helpful drugs for the organism, which contributed to a decrease in the toxicity of metals. Te level of the negative efect of these elements on the biochemical indices of the blood of experimental animals decreased. Keywords | Heavy metals, Intoxication, Rat blood, Blood counts, Biochemical analysis, Biochemical indices RUMIYA TAZITDINOVA 1 , RAIKHAN BEISENOVA 2 , GULNUR SASPUGAYEVA 2 , BAKHYT AUBAKIROVA 2 , ZINA NURGALIEVA 2 , AMANBEK ZANDYBAI 2 , IDIYA FAKHRUDENOVA 1 , AIGUL KURMANBAYEVA 1 Changes in the Biochemical Parameters of Rat Blood under the Combined Efect of Chronic Intoxication with such Heavy Metals as Copper, Zinc, Arsenic Editor | Kuldeep Dhama, Indian Veterinary Research Institute, Uttar Pradesh, India. Received | July 30, 2018; Accepted | August 31, 2018; Published | October 06, 2018 *Correspondence | Rumiya Tazitdinova, Sh. Ualikhanov Kokshetau State University, Kazakhstan, 020000, Kokshetau, Abay Str., 76 Email: irm85@mail.ru Citation | Tazitdinova R, Beisenova R, Saspugayeva G, Aubakirova B, Nurgalieva Z, Zandybai A, Fakhrudenova I, Kurmanbayeva A (2018). Changes in the biochemical parameters of rat blood under the combined efect of chronic intoxication with such heavy metals as copper, zinc, arsenic. Adv. Anim. Vet. Sci. 6(11): 492-498. DOI | http://dx.doi.org/10.17582/journal.aavs/2018/6.11.492.498 ISSN (Online) | 2307-8316; ISSN (Print) | 2309-3331 Copyright © 2018 Tazitdinova et al. Tis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 1 Sh. Ualikhanov Kokshetau State University, Kazakhstan, 020000, Kokshetau, Abay Str., 76; 2 L.N. Gumilyov Eur- asian National University, 010000, Astana, Satpayev Str., 2, Kazakhstan.