International Journal of Contemporary Pediatrics | January 2021 | Vol 8 | Issue 1 Page 120 International Journal of Contemporary Pediatrics Bruntha PJ et al. Int J Contemp Pediatr. 2021 Jan;8(1):120-126 http://www.ijpediatrics.com pISSN 2349-3283 | eISSN 2349-3291 Original Research Article A study of prevalence of abnormal EEG and its association between various clinical presentations of atypical febrile seizures Bruntha Priyavathani J. 1 , Sriram Pothapregada 1 *, Anuradha Varadhan 2 , Suresh C. Thirunavukarasu 3 INTRODUCTION Febrile seizure (FS) is one of the most common neurological disorders in children. The incidence of FS in India varies between 5-10% and it is 8.8% in Japan, and 14% in Guam. 1-4 Variation in prevalence relates to differences in case definitions, ascertainment methods, geographical variation, and cultural factors. FS is classified into simple and complex febrile seizures based on various clinical features such as duration, type, number of episodes, post ictal neurological status and so on. 5 As it is primarily based on history obtained from caregivers, it could be eventually subjective. 2 to 10% of children who have febrile seizures will subsequently develop epilepsy, especially atypical febrile seizure is an independent risk factor for future epilepsy. 6-9 Quantitative electroencephalogram (qEEG) is the mathematical processing and transformation of digitally recorded EEG into a format using various algorithms, 1 Department of Paediatrics, Indira Gandhi Medical College and Research Institute, Puducherry, India 2 Department of Paediatrics, Rajiv Gandhi Government Women and Children Hospital, Puducherry, India 3 Department of Neurology, Indira Gandhi Government General Hospital and Post Graduate Institute, Puducherry, India Received: 30 October 2020 Accepted: 10 December 2020 *Correspondence: Dr. Sriram Pothapregada, E-mail: psriram_ped@yahoo.co.in Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Background: Quantitative EEG is a rapidly emerging tool in the diagnosis and follow up of various neurological disorders and can act as predictive marker for subsequent epilepsy in children with complex febrile seizure. The present study aimed to estimate the prevalence of abnormal electroencephalogram (EEG) and to find the association between Quantitative EEG (qEEG) and various clinical features of atypical febrile seizures(AFS). Methods: EEG was recorded along with clinical features including the age at onset, duration of episode, number of episodes in a day, type of seizure and the recurrences from the children aged between 6-60 months with atypical febrile seizures. EEG recordings were classified into Normal and abnormal EEG with epileptiform changes by the expert interpretation and the distribution of above said clinical features in the both groups were analyzed. It is also attempted to find the association between qEEG and few of the clinical features. Results: Prevalence of abnormal EEG in atypical febrile seizures was 33.9%. There were no significant differences in the distribution of abnormal EEG and their association with various clinical features of AFS. Significantly increased absolute power of θ and α waves were recorded from the frontal montages in the children with epileptiform changes in the EEG. Conclusions: qEEG changes can be also considered as marker of severity of febrile seizure episodes. Many prospective studies with long-term follow up are required to establish the predictability of future epilepsy by qEEG. Keywords: Atypical febrile seizures, Febrile seizures, Prevalence, Quantitative EEG DOI: https://dx.doi.org/10.18203/2349-3291.ijcp20205517