Jemds.com Case Report J. Evolution Med. Dent. Sci./eISSN- 2278-4802, pISSN- 2278-4748/ Vol. 9/ Issue 18/ May 04, 2020 Page 1522 Co-Existence of Chronic Lymphocytic Leukaemia and Malignancy of Uterine Cervix Uttara Vijay Shelke 1 , Shourya Acharya 2 , Deepti Sandeep Shrivastava 3 1 Department of Obstetrics and Gynaecology, Acharya Vinoba Bhave Rural Hospital, DMIMS, Sawangi, Wardha, Maharashtra, India. 2 Department of Medicine, Acharya Vinoba Bhave Rural Hospital, DMIMS, Sawangi, Wardha, Maharashtra, India. 3 Department of Obstetrics and Gynaecology, Acharya Vinoba Bhave Rural Hospital, DMIMS, Sawangi, Wardha, Maharashtra, India. Chronic Lymphocytic Leukaemia (CLL) is the most common variety of leukaemia. In this disease B-lymphocytes which would normally respond to antigens by transformation and forming antibodies, fail to do so. Patients with chronic lymphocytic leukaemia have up to a threefold risk of site specific secondary cancers. However, the co-existence of chronic lymphocytic leukaemia with gynaecological cancers is a rare phenomenon. Expert clinical and pathological review is warranted for proper diagnosis and management. Here we report a case of 57 year old patient with co-existent CLL and squamous cell carcinoma of the uterine cervix. Chronic Lymphocytic Leukaemia (CLL) is the most common leukaemia affecting the western world. It occurs mostly in the elderly. [1] It is less frequent in the Asian population. CLL is characterized by clonal proliferation and accumulation of mature, typically, CD5 positive B-cells within the bone marrow, spleen, blood and lymph nodes. [2] An increased risk of another (second) cancer in patients with CLL was reported in few studies. [3] These second cancers in CLL may be due to patient related risk factors, chemotherapy specific factors such as immunosuppression. Certain studies have given a report that second cancers may occur with similar frequency whether they developed concurrently or after the diagnosis of CLL. Immunodeficiency in CLL may predispose to development of a second cancer. [4],[5] PRESENTATION OF CASE A 57-year-old patient presented to medicine department of this hospital with complaints of generalized weakness, weight loss and fatigue. On clinical examination she had anaemia, splenomegaly 13 cms, firm non tender, below left costal margin. There was no lymphadenopathy. Hb- 7.2 grams. Peripheral smear was suggestive of CLL. Marrow aspirate showed 80% small atypical lymphocyte. She was diagnosed as CLL stage III (Rai staging). Patient received chemotherapy with Cyclophosphamide, Vincristine, Prednisolone and Chlorambucil. Later, in the same month, she presented to gynaecology OPD with complaints of leucorrhoea and bleeding per vaginum since 8 days. On general examination vitals were stable. On per speculum examination bleeding through os was present. On per vaginal examination uterus was atrophied, cervix was pinpoint, fornices were free. Patient underwent total abdominal hysterectomy with bilateral salpingo- oophorectomy with omentectomy without any complications and the specimen was sent for histopathological examination. Patient is on follow up. Corresponding Author: Dr. Sourya Acharya, Department of Medicine, Acharya Vinoba Bhave Rural Hospital, DMIMS, Sawangi, Wardha, Maharashtra, India. E-mail: souryaacharya74@gmail.com DOI: 10.14260/jemds/2020/332 Financial or Other Competing Interests: None. How to Cite This Article: Shelke UV, Acharya S, Shrivastava DS. Co- existence of chronic lymphocytic leukaemia and malignancy of uterine cervix. J. Evolution Med. Dent. Sci. 2020;9(18):1522- 1524, DOI: 10.14260/jemds/2020/332 Submission 06-01-2020, Peer Review 17-04-2020, Acceptance 23-04-2020, Published 04-05-2020. INTRODUCTION