Jemds.com Case Report J Evolution Med Dent Sci / eISSN - 2278-4802, pISSN - 2278-4748 / Vol. 10 / Issue 32 / Aug. 09, 2021 Page 2687 Rivaroxaban Causing Thrombocytopenia in a Case of Deep Vein Thrombosis (DVT) Twinkle Pawar 1 , Yash Gupte 2 , Sourav Chaturvedi 3 , Anusha Gupta 4 , Sourya Acharya 5 1, 2, 3, 4, 5 Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Science, Sawangi, Wardha, Maharashtra, India. Novel oral anticoagulants (NOACs) are used as alternative to intravenous anticoagulants. It includes apixaban, dabigatran, rivaroxaban and edoxaban. 1 Some of the complications induced by these drugs are gastrointestinal haemorrhage, cerebral haemorrhage and rarely thrombocytopenia. We present a rare case report of a selective factor Xa inhibitor rivaroxaban, which induced thrombocytopenia in a case of deep vein thrombosis (DVT) of right lower limb. Drugs commonly used to prevent embolization of systemic circulation are warfarin and novel oral anticoagulants, such as rivaroxaban and dabigatran. A 34-year-old male patient presented to the casualty with the chief complaint of pain and swelling of right lower limb. He denied any history of hypertension, diabetes mellitus, trauma. The patient had no significant past history. On general examination, patient was afebrile with a pulse of 84 per minute, blood pressure of 130/90 mm of mercury, and respiratory rate of 24/min. On local examination, there was swelling on right lower limb with ecchymosis which was indurated and extending to medial malleolus. There were no signs of petechiae or bleeding tendencies. On neurological examination, the patient was conscious and oriented, heart sounds were normal, per abdominal examination was soft and non- tender and chest on auscultation was bilateral clear. Corresponding Author: Dr. Twinkle Pawar, Department of Medicine, Jawaharlal Nehru Medical College, Sawangi, Wardha, Maharashtra, India. E-mail: pawartwinkle@gmail.com DOI: 10.14260/jemds/2021/548 How to Cite This Article: Pawar T, Gupte Y, Chaturvedi S, et al. Rivaroxaban causing thrombocytopenia in a case of deep vein thrombosis (DVT). J Evolution Med Dent Sci 2021;10(32):2687- 2688, DOI: 10.14260/jemds/2021/548 Submission 27-01-2021, Peer Review 10-06-2021, Acceptance 16-06-2021, Published 09-08-2021. Copyright © 2021 Twinkle Pawar et al. This is an open access article distributed under Creative Commons Attribution License [Attribution 4.0 International (CC BY 4.0)] INTRODUCTION PRESENTATION OF CASE