Impact on Physical Activity on Fasting Random Blood Sugar and Hba1C in Type-II Diabetic Patients ISSN (Print): 2521-8514 ISSN (Online): 2521-8484 RADS J. Pharm. Pharm. Sci. 98 ORIGINAL ARTICLE Impact of Physical Activity on Fasting, Random Blood Sugar and HbA1C in Type – II Diabetic Patients Mahmood Sheikh 1 , Sheikh Abdul Khaliq 2, *, Iqbal Azhar 1 , Ejaz Mohiuddin 3 1 Department of Pharmacognosy, Faculty of Pharmacy & Pharmaceutical Sciences, University of Karachi, Pakistan 2 Department of Pharmacy Practice and Pharmaceutics, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan 3 Faculty of Eastern Medicine, Hamdard University, Karachi, Pakistan ABSTRACT Authors’ Contributions 1 Conceived idea, manuscript initial drafting. 2 Study design, final drafting of manuscript. 3 Study supervisor and literature survey. 4 Statistical analysis and final interpretation of results. Acknowledgement Authors acknowledge the support of Shah Makeen, a Diabetes Mellitus Manager, Ali Gohar Pharmaceuticals, Karachi, Dr. Iqbal Ahmed, Homeo Physician, Latif Kapadia Homeopathy Charity Clinic Karachi and Hakim Muhammad Amjad, Hakim, Department of Eastern Medicine, Hamdard University Hospital, Karachi for collection and compilation of data. Article info. Received: January 27, 2020 Accepted: September 12, 2020 Funding Source: Nil Conflict of Interest: Nil Cite this article: Sheikh M, Khaliq SA, Azhar I, Mohiuddin E. Impact of Physical Activity on Fasting, Random Blood Sugar and HbA1C in Type-II Diabetic Patients. RADS J Pharm Pharm Sci. 2020; 8(2):98-105. *Address of Correspondence Author: sheikh1974@gmail.com Objective: Aim of the study is to evaluate the impact of physical activities on fasting, random blood sugar and HbA1C on patients getting treatment with different systems of medicine. Methods: Prospective cross sectional study was conducted in outpatient facilities of Karachi from July 2017 to July 2018 with treatment duration of at least one year. 195 type – II Diabetic patients with confirm diagnosis enrolled in the study. Study has three arms of anti-diabetic treatment; herbal, homeopathic and allopathic. Outcome measures are Fasting Blood Sugar (FBS), Random Blood Sugar (RBS) and HbA1C with and without exercise. Results: In exercise group, mean reduction of FBS in patients; Allopathic=138.31±46.11 mg/dl, homeopathic=100±00 mg/dl, herbal=121.11±19.64 mg/dl, combination=135.20±40.85 mg/dl. Mean reduction of RBS; Allopathic=186.25±58.77 mg/dl, homeopathic=140.00±00 mg/dl, herbal=198.88±49.60 mg/dl, combination=231.90±64.10 mg/dl. Mean reduction of HbA1C; Allopathic=7.53±1.97%, herbal=6.47±0.335%, combination=7.21±1.147%. In patients not doing exercise, mean reduction of FBS in patients; Allopathic=183.80±85.49 mg/dl, homeopathic=119.00±47.71 mg/dl, herbal=131.00±17.68 mg/dl, combination=134.37±49.88 mg/dl. Mean reduction of RBS; Allopathic=240.08±92.76 mg/dl, homeopathic=163.00±32.33 mg/dl, herbal=193.66±46.42 mg/dl, combination=212.67±87.21 mg/dl. Mean reduction of HbA1C; Allopathic=8.89±2.04%, homeopathic=6.40±00%, herbal=6.54±0.398%, combination=7.10±1.53%. FBS is significantly better controlled by allopathic system compare to homeopathic (p=0.004), herbal (p=0.0001), combination (p=0.0001). RBS is significantly better controlled by allopathic system compare to homeopathic (p=0.006), herbal (p=0.017). Homeopathic system significantly better control RBS compare to combination treatment (p=0.036). Conclusion: Physical activities and exercises can provide better control on FBS, RBS HbA1C. Allopathic and combination systems of medicine have better glycemic control in type – II Diabetes Mellitus patients involve in physical activities. Keywords: Exercise, Diabetes mellitus, blood sugar, HbA1C, glycemic control