How to Cite: Mohammed, S. J., & AL-Fartusie, F. S. (2022). Assessment of liver function enzymes, MDA and GSH in the Sera of COVID-19 patients. International Journal of Health Sciences, 6(S5), 4798–4808. https://doi.org/10.53730/ijhs.v6nS5.9623 International Journal of Health Sciences ISSN 2550-6978 E-ISSN 2550-696X © 2022. Manuscript submitted: 27 Feb 2022, Manuscript revised: 9 April 2022, Accepted for publication: 18 June 2022 4798 Assessment of liver function enzymes, MDA and GSH in the Sera of COVID-19 patients Sara Jassim Mohammed Department of Chemistry, College of Science, Al-Mustansiriyah University, Baghdad-Iraq sara.gawi.msc@uomustansiriyah.edu.iq Falah S.AL-Fartusie Department of Chemistry, College of Science, Al-Mustansiriyah University, Baghdad-Iraq Corresponding author email: sci.falah.al_fartusie@uomustansiriyah.edu.iq Abstract---A cluster of unexplained pneumonia cases was reported in Wuhan, China, in late December 2019. A new coronavirus was identified as the causative cause of this mysterious pneumonia a few days later. The World Health Organization has temporarily given this causal virus the designation of severe acute respiratory syndrome coronavirus 2 and the related infected disease as coronavirus disease 2019 (COVID-19). The primary objective of this study is to examine the liver efficiency and assess the oxidative stress status of COVID-19 patients by measuring liver function enzymes, glutathione and MDA. The study included 120 cases ranging from 20 to 60 years, divided into three groups, COVID-19 patients, recovered, and control groups. Group. The results obtained indicated a significant increase in ALT, AST, and ALP activity (p< 0.01) in patients compared to those recovering and control. The results also indicated a significant increase in MDA in contrast to a significant decrease in the GSH activity of COVID-19 patients compared to recovered and healthy subjects. These results reflect the strong relationship between COVID- 19 and impaired liver function as well as impaired oxidative stress / antioxidant balance. Keywords---COVID-19, liver enzymes, Glutathione, MDA. 1. Introduction Coronavirus disease (COVID-19) was initially detected when cases of viral pneumonia were reported in December 2019 in Wuhan, Hubei Province, China [1]Since then, the disease has spread globally and has been declared a global