Contents lists available at ScienceDirect Gait & Posture journal homepage: www.elsevier.com/locate/gaitpost 7-DAYS ACTIGRAPHY in PATIENTS WITH PARKINSON DISEASE: A 2-YEARS FOLLOW-UP C. Tomasi a , E. De Giovannini a , N. Locallo a , F. Favaron a , C. Lain a , P. Pianalto a , V. Terrazzi a , M. Pistacchi b , M. Rabuffetti c a Centro Medico Riabilita Cooperativa Sociale Mano Amica Onlus - Schio (VI) Italy b ULSS 7 PEDEMONTANA Dip. Neurologia, Santorso (VI) Italy c IRCCS Fondazione Don Carlo Gnocchi, Milano, Italy 1. INTRODUCTION Parkinson Disease (PD) features a gradual evolution of clinical outcome, characterized by both motor (resting tremor, bradykinesia, rigid muscles, impaired posture), and non-motor symptoms. The aim of thisstudyistoanalyzetheuseofactigraphs(wearablesensorsforlong- term motor activity tracking [1])fortheevaluationofmotorsymptoms progression in PD patients. 2. METHODS Twelve participants with Parkinson disease under pharmacological treatment and with preserved motor functions were recruited at Centro Medico Riabilita – Mano Amica Onlus (Schio, VI). Inclusion criteria were the absence of camptocormia, severe articular deficits and/or dystonia, diagnosis of dementia, severe dysphagia-dystonia. Furthermore, none of the patients were undergoing infusion therapy or had been subjected to neurosurgery. Patients participated to group activities including motor and logopedic rehabilitation as well as cog- nitive stimulation exercises. Participants were assessed at baseline and at 1-year and 2-year follow-ups. An actigraph with triaxial accel- erometer (Geneactiv, Activinsights Ltd, Kimbolton, UK) was used to record each patient’s motor activity for 7 days at each assessment. Raw data were analysed according [2] producing time profiles of motor activity (MA). The average daily distribution of activity levels let to extracttwoindexes:1)AD,durationofactivebehaviour;2)AP:peakof motor activity, i.e. the activity threshold surpassed for one hour a day. 3. RESULTS Theoutcomeofthethreeassessmentsforeachpatientsarereported in Fig.1 asaADvs.APscatterplot.Controldata(X)wereobtainedfrom 25 age-matched healthy subjects. 4. DISCUSSION The two indexes are intended to summarize and quantify two complementary aspects of daily activity: the time spent active, possibly related to endurance/fatigue, and a peak activity level, related to pa- tientcapacity.Theresultsevidencedthatsuchvaluesarevaluabletools in assessing the evolution of the functional status of a patient affected Fig. 1. 2-year follow-ups (red lines) of patients' duration and peak of daily activities; controls (X). https://doi.org/10.1016/j.gaitpost.2019.07.437 Gait & Posture xxx (xxxx) xxx–xxx 0966-6362/ © 2019 Published by Elsevier B.V.