Furthermore the present study aimed at investigating the strength of interference of irrelevant information when the memory target is known in advance (precue), compared to when it is not (retrocue). Fifteen healthy participants (age 20-30) conducted two tasks in which a varying number of bars (set size two and four) were presented in a serial manner. In both tasks, bars differed in orientation and color and were either preceded by a precue or followed by a retrocue that pointed to the bar, which was relevant during the later test. In the first task, subjects were asked to memorize the orientations and ignore the color of the bars. After presentation of cue and bars, a test bar was presented with the same orientation in each trial, but a different color. The color was either the same as the color of cued target (match), of a distractor (non- match) or a color that was not presented before. By means of a response dial subjects had to adjust the orientation of the bar with regard to the target orientation. The second task was similar to the first. Here subjects were asked to memorize colors and ignore orientations. In the end, a plain bar with varying orientation was presented and color had to be adjusted to the target color. In both tasks, precision was higher for items that were preceded by a precue compared to the retrocue. In addition, precision was reduced in both cuing conditions with larger set size. Irrelevant information of distractors and targets had different impacts on the precision, which was also dependent on the cuing condition and on individual WMC. The results support the model of a WMC limit with flexible resources that can be allocated to the required amount of information instead of a concrete item limit. This study also shows that the prior knowledge of relevant information can be a strong modulator of memory precision as well as irrelevant information. doi:10.1016/j.ijpsycho.2016.07.336 87 QEEG in teenagers with Conduct Disorder and psychopathic traits Ana A. Calzada-Reyes a , Alfredo Alvarez-Amador b , Lídice Galán García b , Mitchell Valdés-Sosa b a Clinical Neurophysiology Department Legal Medicine Institute, Havana, Cuba b Cuban Neurosciences Center, Havana, Cuba Few studies have investigated the impact of the psychopathic traits on the EEG of teenagers with Conduct Disorder (CD). To date, there is no other research studying Low-Resolution Brain Electro- magnetic Tomography (LORETA) technique using Quantitative EEG (QEEG) analysis in adolescents with CD and psychopathic traits. Objective: To find electrophysiological differences specifically related to the psychopathic traits. The current investigation compares the QEEG and the current source density measures between adolescents with CD and psychopathic traits and adolescents with CD without psychopathic traits. Methods: The resting EEG activity and LORETA for the EEG fast spectral bands were evaluated in 42 teenagers with CD, 25 with and 17 without psychopathic traits according to the Antisocial Process Screening Device. All adolescents were assessed using the DSM IV-R criteria. The EEG visual inspection characteristics and the use of frequency domain quantitative analysis techniques (Narrow Band Spectral Parameters) are described. Results: QEEG analysis showed a pattern of beta activity excess on the bilateral frontal-temporal regions and decreases of alpha band power on the left centro-temporal and right frontal-central-temporal regions in the Psychopathic traits group. Current Source Density calculated at 17.18 Hz showed an increase within fronto-temporo-striatal regions in the Psychopathic relative to the Non-psychopathic traits group. Conclusions: These findings indicate that QEEG analysis and techniques of source localization may reveal differences in brain electrical activity between teenagers with CD and psychopathic traits, which was not obvious to visual inspection. Taken together, these results suggest that abnormalities in a fronto-temporo-striatal network play a relevant role in the neurobiological basis of psychopathic behavior. doi:10.1016/j.ijpsycho.2016.07.337 101 Language deficits as a preclinical window into Parkinson’s disease: Evidence from asymptomatic parkin and dardarin mutation carriers Adolfo Garcia-Cordero a,b,c , Lucas Sedeno b,c , Natalia Trujillo a , Yamile Bocanegra a , Diana Gomez a , David Pineda a , Andres Villegas a , William Arias a , Agustin Ibañez b,c,d,e,f a Faculty of Elementary and Special Education (FEEyE), National University of Cuyo (UNCuyo), Argentina b Institute of Translational and Cognitive and Neuroscience (INCyT), INECO Foundation, Favaloro University, CONICET, Buenos Aires, Argentina c National Scientific and Technical Research Council (CONICET), Av. Rivadavia 1917, C1033AAJ, Buenos aires, Argentina d Universidad Autónoma del Caribe, Barranquilla, Colombia e Department of Psychology, Universidad Adolfo Ibáñez, Diagonal Las Torres 2640, Santiago, Chile f Centre of Excellence in Cognition and its Disorders, Australian Research Council (ACR), 16 University Avenue, Macquarie University, NSW 2109, Sydney, Australia The worldwide spread of Parkinson’s disease (PD) calls for sensitive and specific measures enabling its early (or, ideally, preclinical) detection. Here we employ language measures revealing deficits in PD to explore whether similar disturbances are present in asymptomatic individuals at risk for the disease. We administered executive, semantic, verb-production, and syntactic tasks to 33 sporadic PD patients, 8 genetic PD patients with parkin (PARK2) or dardarin (LRRK2) mutation, 9 asymptomatic first-degree relatives of the latter with similar mutations, and socio-demographically matched controls for the clinical and subclinical samples (N = 36 and 20, respectively). Demographic and experimental data were analyzed using ANOVA and Tukey’s HSD post-hoc tests (except for gender, which was analyzed via Pearson chi-square tests). Effect sizes were calculated with Eta squared (n 2 ). Moreover, to detect sui generis language disturbances, we ran ANCOVA tests using executive functions as covariate. In all cases, alpha values were set at p b .05. The two clinical groups showed impairments in all measures (all p- values b .01, all effect sizes N 0.2) most of which survived covariation with executive functions. However, the key finding concerned asymptomatic mutation carriers. While these subjects showed intact executive (p = .25), semantic (p N .09), and action-verb production (p = .14) skills, they evinced deficits in a syntactic test with minimal working memory load (p b .01, n 2 = .26). We propose that this sui generis disturbance may constitute a prodromal sign anticipating eventual development of PD. Moreover, our results suggest that mutations on specific genes (PARK2 and LRRK2) compromising basal ganglia functioning may be subtly related to language-processing mechanisms. [This work was partially supported by grants from CONICET, CONICYT/FONDECYT Regular (1130920), COLCIENCIAS IOP 2016 112