Al-Jowari (2020): Use of eggplant in hyperlipidemia due to antibiotic usage Oct 2020 Vol. 23 Issue 14 http://doi.org/10.36295/ASRO.2020.231407 Annals of Tropical Medicine & Public Health The use of eggplant peel powder in the treatment of hyperlipidemia caused by antibiotics administration in male local rabbits Suha Abdul-Khaliq Al-Jowari 1* 1 Department of Biology, College of Science, University of Baghdad, Baghdad, Iraq. *Corresponding author: suha_aljwari@yahoo.com Abstract This study was denoted to investigate the effect of eggplant peel powder in the treatment of hyperlipidemia caused by antibiotics (amoxicillin and cephalexin) administration in male rabbits. In this study, fifteen male rabbits were used that divided into three groups; the first, the control, the second & third groups were treated with 10 mg/kg amoxicillin and cephalexin, respectively for 14 days. Blood samples were collected from these groups and lipid profile tests were done. Then, the groups which treated with antibiotics were supplied with pellets mixed with 20 mg/kg eggplant peel powder once per day for 21 days. Again, blood samples were taken for lipids assays. Results illustrated a significant (p<0.05) elevation at total cholesterol, triglycerides, lipoproteins, and atherosclerosis index means in the groups treated with these two antibiotics as compared with the control group. Concerning the impact of eggplant peel powder on antibiotics administration, these results showed no significant differences in lipids profile parameters in the groups treated with these two antibiotics and eggplant peel powder except cholesterol and LDL-C in cephalexin group which differ significantly. It concluded that eggplant peel powder act in the treatment of hyperlipidemia caused by antibiotics uptake and this may be due to the elevated levels of anthocyanins in peel powder especially nasunin. Thus, these compounds act to decrease the high concentrations of serum lipids and return them to the normal level. Keywords: Eggplant peel powder, hyperlipidemia, antibiotics How to cite this article: Al-Jowari SA-K (2020): The use of eggplant peel powder in the treatment of hyperlipidemia caused by antibiotics administration in male local rabbits, Ann Trop Med & http://doi.org/10.36295/ASRO.2020.231407 . DOI: ; 23(S14): SP231407 Public Health Introduction Eggplant (Solanum melongena L.) is a vegetable typical food of the Mediterranean regions and consumed worldwide [1- 3] . It is an essential vegetable cultivated over 2 million of the world’s [2] . This vegetable is rich in antioxidant compounds, ranking among the 10 vegetables in terms of antioxidant activity [1, 3-6] . Further, eggplant has an elevated level of free reduced saccharides, anthocyanins, phenols, alkaloids and amides [2] . In addition, it has significant importance in the prevention of some diseases, including cardiovascular disease, liver disturbances, diabetes and tumors [2, 3, 5] . An antibiotic; a chemical compound that kills and prevents the growth of microbial organisms [8] . Multiple studies have investigated to estimate their pharmacodynamic and adverse effects. Adverse effects are multiple, different and dangerous depending on the antibiotics used, microorganisms targeted and period of administration [9, 10] . Amoxicillin; a bactericidal antibiotic that excreted essentially by the kidney; glomerular filtration as well as tubular secretion [8, 9] . Cephalexin is a semisynthetic antibiotic that absorbed when uptake orally. Hypersensitivity is the most common side effect, further, the most side effects include nausea, vomiting, and gastrointestinal (GI) impairment [11] . Hyperlipidemia, due to the alternations in the total lipid, the main reason for heart diseases, such as coronary disease. In many regions, most hyperlipidemic people use herbs and plants to prevent hyperlipidemia and atherosclerosis formation. Natural herbs have few side impacts and many targets, while medical remedy possesses valuable side impacts [12] . Many studies demonstrated that the essential phenolics in eggplant peel are anthocyanins [4] , therefore, the present study aimed to investigate the effect of eggplant peel powder in the treatment of hyperlipidemia caused by these two antibiotics; amoxicillin and cephalexin in male rabbits.