Abstract: Probiotics have been the core area of study since last few decades due to their immense benecial effects on human health. They are widely incorporated as a verity of products in food industry. Prebiotics are the commonly used bers and when used in combination with probiotics are called as synbiotics, thus enhancing the probiotic activity. Several in vitro and in vivo studies have revealed the application of these microbiota management tool for the prevention and cure of diseases. Diarrhea prevention, atopiceczema, dental care, cancer therapy and treatment of bowel syndrome are the various health benets provided by probiotic activity. These wonderful microorganisms have the enzymatic activity of breakdowning the food macromolecules, secretion of anti rnicrobial substances, anti-carcinogenicability, enhancing immune system, improved ability in producing short-chain fatty acid, anti atherogenicability, allergen regulation, anti-virulence activity, treatment of urinary tract infections and many more. In the light of this remarkable ongoing trend and the scientic evidence obtained on these microbiota, it is the need of hour to do further research on dose and optimal probiotic for specic diseases. This narrative review present the current documentation on enteric disease management stratagies and anti- virulence studies focusing on quantum sensing inhibition, anti-toxin effects and anti-invasion effects. Keywords: human health issues; probiotic activity; disease management; Antivirulence activity; next generation probiotics Role of Probiotics in Enteric Disease Management And Their Antivirulence Properties: A Review l l l l l Hasnain Farooq , Kaleem Ullah , Zunair Akma , Amir Hussain Shahzad , Affa Tajamma *, l Aisha Waheed Qureshi WHO has identied probiotics as a non-viable nutritional supplement that provides the host with the health benets by modulating the microbiota. The factor which determines the disease that leads the appearance and propagation of the disease is called the virulence 5 factor for that one . Pathogens adopt a number of Infectious disorders are the main cause of about 18 million deaths every year globally in accordance with the reports of World health organization (WHO). Antibiotic resistance is the major risk factor for the health care sector 1 .Nonpathogenic bacterial associations to their food sources formerly known as prebiotics, probiotics and symbiotics are useful for human health. The substandard food consumption causes allergy, cancer, food poisoning, obesity and cardiovascular diseases due to poor dietetic 2 values of provided nutrients . According to the Metchnikoff, probiotics are the microorganisms which have the ability to change the microbial mixture in the entire human body. Studies have revealed that the oral administration of probiotics twist can treat infantile diarrhea in the children of early age. In view of WHO, probiotics are living microorganisms that promote health benets by increasing or re-establishing the intestinal ora supportive for better intestinal 3 activity .The vast clinical based researches have emphasized on the positive aspects of probiotics in the treatment of illness like chronic cholera syndrome, gastrointestinal disorders, helicobacter removal, diarrhea, uncontrolled fats, antibiotic resistance, controlling diabetes. The report shows the usefulness of probiotics in 4 various types of cancers and other side effects . Introduction: l Department of Biology, Lahore Garrison University, Lahore, Pakistan *afffa.tajammal@lgu.edu.pk AJAHS VOL. 05 ISSUE 03 JULY-SEP 2020