Colloids and Surfaces A: Physicochem. Eng. Aspects 514 (2017) 11–20 Contents lists available at ScienceDirect Colloids and Surfaces A: Physicochemical and Engineering Aspects journal homepage: www.elsevier.com/locate/colsurfa Encapsulation and release of hydrophobic molecules from particles of gelled triglyceride with aminoacid-based low-molecular weight gelators Sebastian-Camilo Salazar-Bautista a,b , Asma Chebil a,b , Guillaume Pickaert a,b , Caroline Gaucher c , Brigitte Jamart-Gregoire a,b , Alain Durand a,b , Michèle Leonard a,b,∗ a CNRS, LCPM, UMR 7375, Nancy, F-54001, France b Université de Lorraine, LCPM, UMR 7375, Nancy, F-54001, France c Université de Lorraine, Faculté de Pharmacie, EA 3452 CITHEFOR, Nancy, F-5400, France h i g h l i g h t s • Aqueous suspensions of polysaccharide-covered particles of gelled oil were prepared. • Various triglyceride oils were used with low amounts of aminoacid- based organogelator. • Antioxidants were encapsulated into the oily core during nanoparticle preparation. • The effect of the structure of antiox- idant on particle characteristics was evidenced. • The kinetics of release of antioxidants out of nanoparticle was monitored and modeled. g r a p h i c a l a b s t r a c t a r t i c l e i n f o Article history: Received 2 October 2016 Received in revised form 12 November 2016 Accepted 15 November 2016 Available online 16 November 2016 Keywords: Organogels Nanoparticles Encapsulation Alkyl gallate Release a b s t r a c t Organogel nanoparticles of triglyceride oils were produced using an aminoacid-based low-molecular weight gelator and a polysaccharide-based stabilizer synthesized by hydrophobic modification of dextran (a non ionic bacterial polysaccharide). The hot liquid organic phase containing the organogelator was emulsified at 70 ◦ C into an aqueous solution of amphiphilic polysaccharide by application of ultrasounds. The resulting sub micrometric oil-in-water emulsion was let cooling down to room temperature leading to an aqueous suspension of gelled oil nanoparticles. The encapsulation of alkyl esters of gallic acid with various alkyl chain lengths (2, 3 and 8 carbon atoms) was carried-out by dissolving these molecules into the hot liquid oil. Octyl gallate (OG) appeared as the most suitable molecule with about 70% of the loaded drug encapsulated into the final particles. The influences of various formulation and process parameters on the final particle size distribution and the yield of encapsulation were examined. The kinetics of release of OG from gelled oil particles was monitored and it was shown that the transport at interface was ∗ Corresponding author at: CNRS, LCPM, UMR 7375, Nancy, F-54001, France. E-mail address: Michele.Leonard@univ-lorraine.fr (M. Leonard). http://dx.doi.org/10.1016/j.colsurfa.2016.11.045 0927-7757/© 2016 Published by Elsevier B.V.