Journal of Science and Technology ISSN: 2456-5660 Volume 7, Issue 01 (JAN-FEB 2022) www.jst.org.in DOI: https://doi.org/10.46243/jst.2022.v7.i01.pp17-27 Published by: Longman Publishers www.jst.org.in 17 | Page Design and Evaluation of Solid Lipid Nanoparticles (SLNs) for Dermal Delivery 1* Nimmathota Madhavi, 2 Sowjanya Battu, 3 Kandikonda Sahaswi, 4 T. Rama Rao 1*,2,3 Department of Pharmaceutics, CMR College of Pharmacy, Medchal, Hyderabad-501401 4 Principal, CMR College of Pharmacy, Medchal, Hyderabad-501401 Corresponding author: Nimmathota Madhavi Email.id: nimmathota.madhavi@gmail.com To Cite this Article Nimmathota Madhavi, Sowjanya Battu, Kandikonda Sahaswi, T. Rama Rao, “Design and Evaluation of Solid Lipid Nanoparticles (SLNs) for Dermal Delivery”, Journal of Science and Technology, Vol. 07, Issue 01, Jan-Feb 2022. Article Info Received: 11-2-2022 Revised: 14-2-2022 Accepted: 18-2-2022 Published:26-2-2022 Abstract: Curcumin has been extensively used in medicine, due to its anti bacterial, anti-inflammatory, antioxidant, and anticancer effects. However, its clinic application is limited by its instability and low solubility. The present work aimed to develop nanoparticles loaded curcumin by spontaneous emulsification solvent diffusion method using Glyceryl monostearate & bees wax along with soy lecithin and Tween 80, to sustain the drug release and to increase the bioavailability. The prepared formulation evaluated for Content Uniformity, Entrapment Efficiency, Particles Size Analysis, In-Vitro Drug Release Studies, Scanning Electron Microscopy. Based on various evaluation parameters formulation F5 was selected as optimized formulation. It was observed that Formulations F5 gave maximum drug release within time. All formulations were subjected for drug release kinetics studies viz. Zero order, First order, Higuchi matrix, Peppas model equations and the formulations F5 followed zero order release with non-fickian diffusion mechanism. Key words: Curcumin, Glyceryl monostearate, Tween 80 INTRODUCTION Even though oral medication is most preferable, produces many issues which includes need to take them several times per day to keep the administered drug concentration inside the therapeutically efficient range, that results in a vary medicine-level and, as a consequence, unwanted noxious and inefficiency 1,2 . To address these issues with traditional oral dose forms, the concept of controlled drug delivery system (DDS) was developed 3 . The major complication in mounting a controlled DDS is not entirely controlling active ingredient-release, but also expanding the period of the dosage form's residence in the absorption-site until every part of the active-ingredient is released completely within the desired time frame 4,5 . Polymers that release the active-ingredient in a synchronized way owing to polymer breakdown over time that cast-off to furnish continuous drug release, that possibly accomplished by utilizing drug carrying polymer. Many literature reports are available on curcumin loaded nanoparticles. The researchers reported for different method of preparations for development of curcumin solid lipid nano particles for their effective drug delivery. Sri Vishnu Kiran Rompicharla et al., reported that cytotoxic capability and induction of apoptosis is improved using Poloxamer-188, cholesterol by enclosing lipid solution with curcumin 6 . Dai et al., developed curcumin-loaded solid lipid nanoparticles using Emulsion- evaporation and low temperature-solidification technique and reported on maximium entrapment efficiency has been achieved 7 . Tiantian Chen et al., proved that Curcumin-SLNs could be a potential chemotherapeutic formulation in the treatment of breast cancer therapy 8-9 . The objective of the present work is to develop Nanoparticles loaded curcumin by ‘spontaneous-emulsification-solvent-diffusion-method’ using polylactin-co-glycolic acid & D-alpha- tocopheryl poly (ethylene glycol) 1000-succinate as a polymer, to sustain the drug-release to increase the bioavailability.