_____________________________________________________________________________________________________ ++ Assistant Professor; # Professor; *Corresponding author: E-mail: ajit.singh1@sharda.ac.in; J. Int. Res. Med. Pharm. Sci., vol. 19, no. 2, pp. 14-23, 2024 Journal of International Research in Medical and Pharmaceutical Sciences Volume 19, Issue 2, Page 14-23, 2024; Article no.JIRMEPS.12042 ISSN: 2395-4477 (P), ISSN: 2395-4485 (O) An Overview of Red Blood Cell Properties and Functions Ajit Pal Singh a++* , Neelesh Kumar Maurya b++ , Rahul Saxena c# and Suyash Saxena c++ a Department of Medical Lab Technology, SSAHS, Sharda University, Gr. Noida, U.P, India. b Department of Nutrition and Dietetics, School of Allied Health Science, Sharda University, Greater Noida, U.P, India. c Department of Biochemistry, SSAHS, Sharda University, Gr. Noida, U.P, India. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.56557/JIRMEPS/2024/v19i28667 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://prh.ikprress.org/review-history/12042 Received: 15/02/2024 Accepted: 18/04/2024 Published: 27/04/2024 ABSTRACT Haematopoiesis, the process of forming blood cells, changes dynamically throughout life. It starts in the yolk sac and moves to the liver around the sixth week, where it produces small erythrocytes. After three months of foetal development, haemoglobin converts into foetal myoglobin, and the spleen becomes a new site for haematopoiesis. Blood-forming cells begin to colonise the medullary chambers of all bones in the fourth month, and this process continues until the child is four years old. Except for the axial skeleton, peripheral bone cavities become hematopoietically dormant when they fill with adipose tissue during adulthood. In some pathological situations, the liver and spleen may re-establish hematopoietic sites. The article discusses RBCs' unique structure, including their biconcave form, lack of a nucleus, and excess haemoglobin, which gives them their distinctive red colour. The article provides a detailed explanation of RBCs' role in oxygen transport, emphasising Review Article