Results: The prevalence of malnutrition in our patients (72.116.90 years) was 39.44% (n=28) but no patient fell into severe malnutrition group. The sociodemographic characteristics were similar except for albumin level (P<0.001). There were no significant statistical differences in PaO 2 , PaCO 2 and PH among three nutritional groups. The nutritional status was not associated with airflow limitation severity, acute exacerbation frequency as well as frequent exacerbation. Conclusion: The study found that the nutritional status based on albu- min level has no correlation with PaO 2 , PaCO 2 , PH , airway limitation severity and acute exacerbation frequency in these subjects. Studies has indicated that albumin level is associated with blood gas analysis parameters, but whether it can be a better indicator to evaluate nutritional status for elderly AECOPD patients with respiratory disease need to be further investigated. AP1649 FACTORS ASSOCIATED WITH SMOKING STATUS IN COPD PATIENTS AISYA NATASYA MUSA 1 , KHAIRIL KHUZAINI ZULKIFLI 1 , MUHAMMAD AMIN IBRAHIM 1 , NURUL YAQEEN ESA 1 , MOHD ARIF MOHD ZIM 1 , AHMAD IZUANUDDIN ISMAIL 1 1 Universiti Teknologi MARA (UiTM), Sungai Buloh, Malaysia Main aetiology in COPD is cigarette smoking. Despite that some of the COPD patients continue to smoke. This study assess the factors associ- ated with smoking status in our COPD patients Method: This is a secondary analysis from a study of dysglycaemia in COPD patients. It is a cross-sectional study involving patients with established COPD (n=186) attending respiratory specialist clinics in UiTM, Selangor, Malaysia. Results: 186 patients were included in the analysis. 95.2% were male. Mean age was 67.99.1 year. 68.8% had primary or secondary education. Majority of the household income was between RM3000–5000 (40.9%). 27.4% were working while the rest were retired or unemployed. 78% lives in urban or suburban area. 24.7% still actively smokes, 71.5% were ex-smokers and 3.8% were never smoker. Mean pack year was 46.624.9. Mean duration of COPD diagnosis was 3.7  2.4 years. Mean FEV1 was 51.4%20.4%. Majority were GOLD D (55.4%), followed by B (22%), C 16.7% and A 5.9%. 40.9% had at least 1 acute exacerbation of COPD within the last year. Comorbidities include ischaemic heart disease (28.5%), dyslipidaemia (43%), hypertension (60.8%) and diabetes (30.1%). Current smokers had a statistically significant lower mean age com- pared to ex/never smoker (63.08.9 vs. 69.58.6, P<0.001). There was a higher proportion of ex/non-smoker vs. active smoker in those not work- ing vs. those working (78.6% vs. 21.4%, χ2=10.209, P=0.001). Other factors such as gender, BMI, pack years, education status, household income, area of residences, duration of diagnosis, number of acute exacerbation in last year, FEV1, comorbidities, recent acute exacer- bation within1 year or GOLD staging, had no significant difference between active smokers and ex/non-smoker. Discussion: This study suggests that older age and not working reduces the likelihood of active smoking in COPD patients. This may highlight the importance of increasing costs of the cigarette in smoking cessation. AP1651 ABSTRACT WITHDRAWN AP1653 STABLE CLINICAL COURSE OF COPD PATIENTS IN THE ERA OF DUAL BRONCHODILATOR THERAPY: THE REAL- WORLD DATA SUN HYE SHIN 1 , NOEUL KANG 1 , JUHEE CHO 2 , HYE YUN PARK 1 1 Division of Pulmonology and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea and 2 Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul, Korea Introduction: Before the introduction of dual bronchodilator therapy, about 50% of chronic obstructive pulmonary disease (COPD) patients eventually progress to receive triple therapy within three years after diag- nosis, which result in overuse of inhaled corticosteroid (ICS). This study aimed to investigate whether the use of dual bronchodilator could be maintained without adding ICS. Methods: This is a retrospective cohort study at single referral hospital. COPD was defined as post-bronchodilator FEV1/FVC < 0.7 and age ≥ 40 years. Between Jan 2015 and Dec 2018, consecutive patients who have used dual bronchodilator therapy for at least 6 months were included in this study. Primary outcome was addition of ICS, regardless of the reason. Results: Among 224 included patients, 54 (24.1%) had previous his- tory of ICS use. During the median follow-up of 20 months, 39 (17.4%) of patients received ICS. At 36 months, 74% of patients were continuing dual bronchodilator therapy without adding ICS. Overall rates of ICS addi- tion did not differ by age, sex, smoking status, previous ICS use, baseline lung function, or blood eosinophil. Conclusions: Dual bronchodilator therapy could be maintained in most of COPD patients without adding ICS. AP1654 A DIFFERENCE ANALYSIS FOR BLOOD ROUTINE TEST INDEXES OF COPD PATIENTS IN ACUTE EXACERBATION PHASE, RECOVERY PHASE AND STABLE PHASE YIJUN CHEN 1 , YUANDI WANG 1 , ZHE ZHANG 1 , QIASHENG LI 1 , ZHENYU LIANG 1 , YING FANG 1 , WENHUA JIAN 1 , JINPING ZHENG 1 1 National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China Background and Aims: To explore the differences of haematological variables in COPD patients between acute exacerbation phase (AE), recovery phase (RE) and stable phase (ST). Methods: The newest inpatient and outpatient records of patients diagnosed as AECOPD from 2012.11 to 2019.2 were collected. 1733 patients with complete blood routine test (BRT) results both in AE and RE were included, among which 53 patients also had results of ST in outpa- tient records. Patients’ Clinical characteristics were collected, including results from the first and last BRT in hospitalization during the AE and RE, and the BRT of outpatient during ST. 1733 patients’ results of BRT in AE and RE were self-compared, among which 53 patients with ST results were compared in 3 groups, and besides, results from AE, RE and SP were compared in pairs respectively. Results: ①Differences of 1773 patients’ BRT indexes between their AE and RE during their hospitalization was analyzed by Wilcoxon test. White blood cell(WBC), neutrophil(NEUT), lymphocyte(LYM), Editorial material and organization © 2019 Asian Pacific Society of Respirology. Copyright of individual abstracts remains with the authors. Respirology (2019) 24 (Suppl. 2), 98–261 172 Abstracts