17 ISSN (print) 2958-471X Journal of National Institute of Laboratory Medicine and Referral Centre Bangladesh Vol.1, No.1, June 2021 1. Lecturer, Sheikh Hasina Medical College, Tangail, Bangladesh; 2. Indoor Medical Officer, Dhaka Medical College Hospital, Bangladesh; 3. Professor, United Medical College, Dhaka, Bangladesh; 4. Lecturer, Colonel Maleque Medical College, Manikganj, Bangladesh; 5. Senior Lecturer, TMSS Medical College, Bogura, Bangladesh; 6. Senior Lecturer, United Medical College, Dhaka, Bangladesh; 7. Junior Scientific Officer, Bangladesh Specialized Hospital Limited (BSHL); 8. Assistant Professor, Ad-din Akij Medical College, Khulna, Bangladesh; 9. Lab. Scientific Officer, Novus Clinical Research Services Limited (NCRSL), Dhaka, Bangladesh. Correspondence: Md. Ashiqur Rahman, Lab. Scientific Officer, Novus Clinical Research Services Limited, Dhaka, Bangladesh. Email: ararashiqur@ gmail.com, Mobile: 01750598938, Orcid id: 0000-0002-9430-5547. Conflict of interest: There is no conflict of interest relevant to this paper to disclose. Funding agency: This research project was not funded by any group or institution. How to cite this article: Chanda M, Biswas T, Roy MN, Sampa SR, Saha P, Sharna RJ, Islam S, Mahbub A, Rahman MA. Association of Liver Enzymes and Lipid Profile in Adults at Tertiary Level Hospital in Bangladesh. J Natl Inst Lab Med Ref Bangladesh, 2021;1(1):17-24. Copyright: ©2021. Chanda et al. Published by Journal of National Institute of Laboratory Medicine and Referral Centre Bangladesh. This license permits use, distribution and reproduction in any medium, provided the original work is properly cited, and is not used for commercial purposes. [Received on: 14 March 2021; Accepted on: 8 May 2021; Published: 1 June 2021] Original Article Association of Liver Enzymes and Lipid Profile in Adults at Tertiary Level Hospital in Bangladesh Manashe Chanda 1 , Tapos Biswas 2 , Manindra Nath Roy 3 , Sharmin Rahman Sampa 4 , Prianka Saha 5 , Rawnok Jahan Sharna 6 , Sadia Islam 7 , Afsana Mahbub 8 , Md. Ashiqur Rahman 9 Abstract Background: The prevalence of dyslipidemia, a primary cause of cardiovascular disorders, is rising quickly in Bangladesh and other Asian nations. Abnormal lipid levels are known to create problems not just in the cardiovascular system but also in the hepatic and renal systems. The information on dyslipidemia and There is little information on its association to liver enzymes in the Bangladeshi population. Methods: This cross-sectional analytical study was conducted from 1st March, 2019 to 29th February, 2020 at the Department of Biochemistry, Sir Salimullah Medical College, Dhaka, Bangladesh. A total of 140 blood samples were collected from apparently healthy adults aged >18 years. SUA, liver enzymes, lipid profile and other biochemical markers were measured in the collected samples by using standard methods. All statistical analyses were performed by using SPSS version 22.0 software and p<0.05 was considered statistically significant. Results: A total of 140 subjects were selected. Among them 70 were male and 70 were female. Serum uric acid (SUA), ALT, AST and GGT levels were significantly (p<0.001) higher in male than female group. AST showed significant positive correlation with TGL, TC, VLDL-C and LDL-C. There was significant positive correlation between ALT and TGL, TC, VLDL-C, ALP showed significant correlation with TC (p=0.027). GGT was significant positively correlated with TGL and VLDL-C. Serum HDL-C was significantly negatively correlated with all enzymes except ALP (p=0.852). Conclusion: The results obtained for the 140 patients studied gave a very good correlation between lipid profile and all the Liver Function Tests. More prospective studies are needed to clarify the complex relationship between lipid profile and liver enzymes in the general population. Keywords: Lipid Profile; Liver Enzyme; Serum Uric Acid; Dyslipidemia; Cardiovascular Disease. ISSN (print) 2958-471X Journal of National Institute of Laboratory Medicine and Referral Centre Bangladesh Introduction Dyslipidemia is regarded as a global public health concern and a significant factor in cardiovascular diseases (CVDs) 1,2 . According to research conducted in recent decades, dyslipidemia is more common than before in the general population 2 . Additionally, a shift in the epidemiology of dyslipidemia has been seen between Journal of National Institute of Laboratory Medicine and Referral Centre Bangladesh June 2021, Vol.1, No.1, P 17-24