Hypertension in Pregnancy, 29:148–152, 2010 Copyright © Informa UK Ltd. ISSN: 1064-1955 print / 1525-6065 online DOI: 10.3109/10641950902928571 LHIP 1064-1955 1525-6065 Hypertension in Pregnancy, Vol. 1, No. 1, May 2009: pp. 1–6 Hypertension in Pregnancy Digitalis-Like Induced Arrhythmia in a Patient with Rheumatic Mitral Regurgitation Complicated by Preeclampsia Digitalis in Preeclampsia Roscani et al. Meliza G. Roscani MD, 1 Silméia G. Zanati MD, 1 Cláudia G. Magalhães MD, 2 Vera T. M. Borges MD, PhD, 2 and Beatriz B. Matsubara MD, PhD 1 1 Department of Internal Medicine, Botucatu Medical School, Unesp, São Paulo State, Brazil 2 Department of Gynecology and Obstetrics, Botucatu Medical School, Unesp, São Paulo State, Brazil Objective. To report a case of cardiac arrhythmia related to a low dose of endovenous lanatoside C. Case report. A 23-year-old pregnant woman with mitral regurgitation complicated with preeclampsia and pulmonary edema presented 2 episodes of atrial tachycardia induced by a intravenous digitalis (2 mg, IV and 1 mg, IV, respectively). Conclusion. This case calls attention to the need for further studies analysing the security of digoxin use in preeclampsia. Keywords Heart failure, Preeclampsia, Case report, Mitral regurgitation, Digitalis. INTRODUCTION Endogenous digoxin-like immunoreactive substances (DLIS) have been described in several pathological conditions including pregnancy-induced hypertension (1,2). It is not known if these substances have any harmful car- diovascular effect in patients with volume-expanded conditions (3). We report herein a case of atrial tachycardia induced by a very low dose of digitalis Address correspondence to Meliza Goi Roscani, Department of Internal Medicine, Botucatu Medical School. São Paulo, Brazil 18618-000, Distr. Rubião Junior, Botucatu, SP, Brazil. E-mail: meliza10@hotmail.com