Ayush Soni et al, International Journal of Pharmaceutical Sciences and Medicine (IJPSM), Vol.9 Issue. 4, April- 2024, pg. 44-54 ISSN: 2519-9889 Impact Factor: 5.9 © 2024, IJPSM All Rights Reserved, www.ijpsm.com 44 Formulation and Evaluation of Ocular in situ Gel of Framycetin Sulfate Ayush Soni; Sunita Sonartiya; Neelam Patel; Rajat Pawar Swami Vivekanand College of Pharmacy, Indore DOI: 10.47760/ijpsm.2024.v09i04.005 ABSTRACT: The aim of the present study was to formulate and optimize Framycetin sulfate in situ gels for the used for treatment of ocular eye infection .it was formulated as ocular in situ gel forming eye drop are using polymers such as carbopol 940 as a gelling agent in combination of suitable preservatives. It is a newer approach to improve easy to eye instillation residence time and enhance bioavailability, prolonged and sustained drug release. in-situ gel formulation using a suitable phase transition polymer to effectively deliver the drug into eyes with sustained and prolonged release and enhanced drug bioavailability. It is observed from the formulation F3 which shown drug content 96.16 % and have good gelling capacity. Thus, it can be concluded that the drug given in the form of ocular in situ gel of Framycetin sulfate providing better patient compliance and an effective mode of treatment. Keywords: Framycetin sulfate, carbol 940, in situ gel, ophthalmic gel, sustained drug release. INTRODUCTION Ocular drug delivery is an extremely important topic, especially with the recent development of new drugs for the treatment of different eye diseases. An ideal drug therapy achieves effective concentration of drug at the target for a specified period of time in order to minimize general and local side effects. Eye is most interesting organ due to its drug disposition characteristics. Generally, topical application of drugs is the method of choice under most circumstances because of its convenience and safety for ophthalmic chemotherapy. Since past few decades, there has been plenty of research reports exhibiting potential of controlled and sustained drug delivery systems. Moreover, various approaches that have been attempted to increase the bioavailability and the duration of the therapeutic