This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/jopr.13075. This article is protected by copyright. All rights reserved. Title Virtual Evaluation of the Accuracy of Fit and Trueness in Maxillary Poly(etheretherketone) Removable Partial Denture Frameworks Fabricated by Direct and Indirect CAD/CAM Techniques Running Title Fit and Trueness of CAD/CAM Maxillary PEEK RPD Authors (First [Given name] Middle Last [Family name]) Enas Elhamy Negm, DDM, Faten Ahmed Aboutaleb, PhD, & Ahmed M Alam-Eldein, PhD Institution Department of Removable Prosthodontics, Faculty of Dentistry Tanta University, Tanta, Egypt Correspondence: Enas Elhamy Negm, Department of Removable Prosthodontics, Faculty of Dentistry Tanta University, Kafr El-Sheikh Muftah, Box 31111, Al-Santa, Gharbia, Egypt. E- mail: enas.negm@yahoo.com Enas Negm https://orcid.org/0000-0003-2011-8949 The authors deny any conflicts of interest in regards to the present study. ABSTRACT Purpose: To compare the accuracy of fit and trueness of maxillary poly(etheretherketone) (PEEK) removable partial denture (RPD) frameworks fabricated by direct and indirect computer-aided design/computer-aided manufacturing (CAD/CAM) techniques. Material and Methods: A definitive maxillary class I master epoxy model was duplicated to create a stone cast. The cast was scanned, and an RPD was designed. Standard tessellation language (STL) data were used to fabricate 20 identical RPD frameworks using 2 CAD/CAM