BACKGROUND Speckle-tracking imaging is a novel method for assessing left ventricular function and ischemic changes. The aim of this study was to predict the presence of coronary artery disease by longitudinal 2-dimensional strain analysis using speckle tracking echocardiography in patients with stable or unstable angina with no regional wall motion abnormality at rest. METHODS This cross-sectional study included a total 66 patients (mean age, 51.92  8.9 years) with suspected coronary artery disease without regional wall motion abnormality on resting echocardiogra- phy who underwent coronary angiography. Longitudinal 2 dimen- sional strain analysis by speckle tracking echocardiography was performed in all patients before coronary angiography. Global and segmental peak systolic longitudinal strain were recorded and computed by offline dedicated software semi-automatically on bull’s- eye report. The patients were divided into two groups according to the coronary angiographic findings; group-I: significant CAD on coronary angiogram (n¼35) group-II: normal coronaries on CAG (n¼31) All the baseline characteristics and outcome were then compared between the two groups. RESULTS Peak systolic longitudinal strain of all left ventricular seg- ments was obtained successfully in 66 patients. Peak systolic longi- tudinal strain (both global and segmental) was significantly decreased in patients with significant coronary artery disease on coronary angiogram group. Receiver operating characteristic curve analysis demonstrated that global peak systolic longitudinal strain could effectively detect patients with coronary artery disease (area under a receiver operating characteristic curve¼0.877, 95% CI¼0.749–0.960). According to receiver operating characteristic curve analysis, - 18.77% appeared to be a good cutoff value for predicting those with signifi- cant CAD (specificity 77.4% and sensitivity 82.9%). Distribution of groups by 2-D strain parameters using Speckle tracking echocardiography (n¼66) Strain parameters Group I (n[35) with significant CAD Group II (n[31) With normal CAG p-value (Mean ± SD) (Mean ± SD) Global PSLS (%) -16.88  2.2 -20.60  2.8 < 0.001 S Segmental PSLS Basal PSLS (%) -15.25  2.7 -18.05  2.4 < 0.001 S Mid- PSLS (%) -16.79  2.3 -20.07  2.9 < 0.001 S Apical PSLS (%) -18.74  3.4 -23.83  4.3 < 0.001 S Mid & Basal PSLS (%) -16.01  2.3 -19.12  2.6 < 0.001 S PSLS, Peak systolic longitudinal strain. S¼Significant, p-value reached from unpaired t-test, p-value significant < 0.05 CONCLUSION The study showed that resting peak systolic longitu- dinal strain (Global & segmental) is significantly reduced and highly sensitive to detect significant CAD in patients with chronic stable angina, even when resting wall motion and left ventricular ejection fraction was normal. It is also observed that 2-dimensional speckle tracking echocardiography seems capable of identifying high-risk patients with left main & triple vessel disease. Therefore, 2-dimen- sional strain using speckle tracking echocardiography with automated function imaging technique may be a more sensitive marker than wall motion abnormality for ischemic heart disease. OTHER: OTHER (UNCLASSIFIED) (TCTAP A-081 TO TCTAP A-087, TCTAP A-141 TO TCTAP A-146, TCTAP A-153) TCTAP A-081 Influence of Low Glycemic Diet on Lipid Profile in Patients with Ischemic Disease of the Heart After Percutaneous Intervention Bakhrom Alyavi, 1 Jamol Uzokov, 1 Djamshid Payziev 1 1 Republican Specialized Scientific-practical Medical Center of Therapy and Medical Rehabilitation, Uzbekistan BACKGROUND The aim of this study was to estimate the influence of the low glycemic index diet on lipid profile inpatients with ischemic disease of the heart after percutaneous interventions. METHODS This study was conducted from 2016 June till 2017 August in our Interventional Cardiology department enrolling 92 patient- s(m¼52; aged 42-71 year; mean age 56.8  12.0 year;) with ischemic disease of the heart after stenting in coronary arteries of the patients. The patients randomly divided into two groups by 46. In the first group patients were assigned low glycemic diet and in second (con- trol) group patients were advised to continue their routine diet during the 3 months on the background of standard therapy. Laboratory and instrumental data were obtained at baseline and after the 12 weeks of the intervention. RESULTS There were no statistic differences in biochemical data be- tween two groups at their baseline characteristics. Low glycemic diet had a positive impact on low-density lipoprotein (LDL, p¼0.02), tri- glyceride (p¼0.005) and very low lipoprotein (VLDL) concentrations (p¼0.04) compared to those patients who used their routine diet. High-density lipoprotein (HDL) was not changed significantly with low glycemic diet. A strong positive correlation was observed between the glycemic index and LDL (mg/dl), (r¼0.72; p¼0.01) and between glycemic index and triglyceride (mg/dl), (r¼0.62; p¼0.03) in the first group compared to the control group. CONCLUSION Low glycemic diet improves lipid profile by reducing LDL and triglycerides in patients with ischemic disease of the heart after percutaneous interventions, and superior to control lipid profile in those patients compared with the routine diet. TCTAP A-082 Sirolimus Coated Balloon: Long Term Results from NANOLUTE Real World Study Sameer Dani, 1 Keyur Parikh, 2 Ranjan Shetty, 3 N Prathap Kumar, 4 Jagdish Hiremath, 5 Dinesh Shah 6 1 Life Care Institute of Medical Sciences & Research & Apollo Hospitals, Ahmedabad, India; 2 Care Institute of Medical Sciences, Ahmedabad, Gujarat, India; 3 Kasturba Medical Collage, Manipal, Mangalore, Karnataka, India; 4 Meditrina Hospital, Kollam, Kerala, India; 5 Ruby Hall Clinic, Pune, Maharashtra, India; 6 William Beaumont Hospital, Michigan, USA BACKGROUND Drug-coated balloons are developed to address the in- stent restenosis (ISR) and stenosis in small coronary vessels. The present study aimed to investigate the immediate performance, mid and long-term results of Magic touch Sirolimus coated balloon (SCB) (Concept Medical) for the treatment coronary stenosis. METHODS The NANOLUTE is prospective, multicentre study real- world study in which 424 patients presenting with stenosis in coro- nary vessels are allocated to the treatment with Magic touch SCB. The main endpoint of the present study was major adverse cardiac event (MACE) up to 1 year. We also calculated MACE at 2 years to assess the long-term performance of SCB. MACE was delineated as a composite of target lesion revascularization (TLR), target vessel myocardial infarction (TV-MI) and cardiac death. RESULTS 424 patients were included in the study, with total of 502 PCI procedures on 451 lesions, all treated with SCB. Of 451 lesions, 204 (45.23%) were ISR lesions whereas 247 (54.77%) were de-novo lesions. 44.58% patients had history of diabetes mellitus and 46.93% patients had hypertension. Overall SCB angioplasty was successful in 99.53% of the cases while 2 vessel dissections were reported. The vessel dis- sections were managed by additional stenting. 91.98% (390/424) pa- tients had completed 1 year follow up. Follow up for the rest of the patients is yet to come as NANOLUTE is on-going study. The incidence of MACE of at 1 year was reported as 4.36%. MACE rate is broken down in TLR (3.85%), TV-MI (0.26%) and cardiac death (0.26%). Long term 2-year results are equally encouraging with MACE of 5.10% in 78.53% (333/424) without increment of any event. CONCLUSION The study demonstrated, in this all comers study, the use of SCB resulted in good procedural outcome along with lower rate of MACE in patients with lesions in coronary arteries at 1 year. The results are very promising in long-term follow up of 2 years. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, VOL. 71, NO. 16, SUPPL S, 2018 S45