THE DOMINANCE ROLE OF PHYSICS IN PHARMACEUTICAL DOSAGE FORM FORMULATIONS: A ROBUST PRODUCT DEVELOPMENT Rahul Pal 1 , Prachi Pandey 2 , Kavya 3 , Neelu 4 , Priyanka Pal 5 , Sudhanshu Singh 6 , Ravi Pal 7 * 1,2,3,4 Department of Pharmaceutics, NIMS Institute of Pharmacy, NIMS University Jaipur, Rajasthan, 303121, India. 5 Research Scholar, GRS College of Pharmacy Kalan Shahjahanpur, India. 6 Research Scholar, Department of Pharmacy, Invertis Institute of Pharmacy, Invertis University, Bareilly, India. 7 Assistant Professor, JMB Institute of Life Science and Higher Education, Madhotanda Road Pilibhit, UP, India. Abstract: Pharmacy's physical branch delves into the use of physics and chemistry in the field of pharmaceuticals. In essence, this involves the examination of the influence of dosage forms on their respective environments at a molecular scale. Physics have the dominance in the formulation for the pharmaceutical dosage that are either in solid, gas and liquid form. Physics of pharmacy is known as rheology science that concerns with the deformation of the solids and flow of the liquids. Physics involves pressure, motion, fluid flows, and energy losses in formulating solid, gas, and liquid dosages. Physics is involved in various pharmaceutical technological analysis including such as study utilized a combination of analytical techniques, including differential scanning calorimetry (DSC), X-ray powder diffraction, solid-state spectroscopy, UV-Visible absorption spectroscopy, and FT-IR spectroscopy, involving key role for the formulation with their uses perfectly. In this review article main highlights points considering initially means of fluid dynamics with the fluid flow which are such as laminar, turbulent and transition flow which are determined by the using Reynold’s Number via Reynold’s apparatus. Difference between newtonian flow and non-newtonian flow which are time dependent or time independent, flow is measured by the orfice meter, pilot tube and rotameter and many more. Lastly the physics of compression of tablet formulation which are explained with removal of gaseous phase (air) and further proceed for the tablet manufacturing including parameters followed during compression of individual tablet and some of the pre-formulation of character of given powder or tablet. Keyword: Physics, Flowability, Newtonian, Non-Newtonian Flow, Tablet Compression and Compaction. ISSN NO 0017 - 2715 Page no :125 DOI:12.163022.Gj.2023.v16.05.0023 Goya Journal Volume 16, Issue 5 2023