This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/JVH.13247 This article is protected by copyright. All rights reserved PROF. MARK SONDERUP (Orcid ID : 0000-0001-7128-8329) DR. HAILEMICHAEL DESALEGN (Orcid ID : 0000-0003-2042-5797) DR. MAUD LEMOINE (Orcid ID : 0000-0002-9011-2991) Article type : Commissioned Review Running title: Determining Hepatitis B treatment need in sub-Saharan Africa TITLE: Hepatitis B in sub-Saharan Africa – how many patients need therapy? Mark Sonderup 1 , Geoffrey Dusheiko 2 , Hailemichael Desalegn 3 , Maud Lemoine 4 , Christian Tzeuton 5 , Simon D. Taylor-Robinson 4, C. Wendy Spearman 1 1. Division of Hepatology, Department of Medicine, Faculty of health Sciences, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa 2. Liver Unit, Kings College Hospital, London, UK; Division of Medicine, University College London Medical School, London, UK 3. Medical Department, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia 4. Department of Surgery and Cancer, Liver Unit, St Mary's Hospital NHS, Imperial College London, UK 5. Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon. Corresponding author: mark.sonderup@uct.ac.za Accepted Article