International Journal of Interdisciplinary and Multidisciplinary Studies (IJIMS), 2014, Vol 1, No.6, 122-134. 122 Available online at http://www.ijims.com ISSN: 2348 – 0343 Recent Trends in Sustained Release Drug Delivery System Asha Gandhi * , SL Hari Kumar Rayat & Bahra Institute of Pharmacy, Sahauran, Mohali, Punjab. *Corresponding author: Asha Gandhi Abstract Now a days as very few drugs are coming out of research and development and already existing drugs are suffering the problem of resistance due to their irrational use specifically in case of drugs like antibiotics. Hence, change in the operation is a suitable and optimized way to make the some drug more effective by slight alteration in the drug delivery. Keywords: Sustained release system, Matrix system Introduction Sustained Release Drug Delivery System For every disease or disorder state of the patient, proper medication is of prime importance to maintain the patient in good health. To achieve this, the medicine or drug is administered Conventionally by one or more of several well defined and popular routes of drug administration Including oral, parentral, rectal, alveolar, and Ocular and topical. Among these above mentioned popular routes, oral conventional route of drug administration lies at the top of the hierarchy of the conventional routes. 1 Now a day’s most of the pharmaceutical scientists are involved in developing an ideal DDS. Scientists have succeeded to develop a system that can be as near to an ideal system and it encourages the scientists to develop controlled release system. 2 For this reason, most system employed are of the sustained release variety.This ideal system should have advantage of single dose for whole duration of the treatment and it should deliver the drug directly at specific site. Prolonged-release tablets, also known as sustained-release tablets or extended-release tablets are tablets formulated in such a manner as to make the contained active ingredient available over an extended period of time after ingestion. 3 A sustained release (SR) tablet is typically designed to release drug over 12-24 hrs and might contained in an immediate release tablet. 4 The USP/ NF presently recognize several types of modified release dosage forms. 1  Delayed released dosage forms (Ex: enteric coated tablets)  Extended released dosage forms (Ex: sustained released dosage forms, Controlled release dosage forms). Modified Release dosage form