Acta Scientific Pharmaceutical Sciences (ISSN: 2581-5423) Volume 7 Issue 6 June 2023 Development and Characterization of Vanishing Cream Shashank Yadav 1 , Prerana Sahu 1 , Prachi Bhimte 1 , Nemendra Sahu 1 , Shweta Sarparaj 1 , Harish Sharma 2 and Gyanesh Kumar Sahu 2 * 1 Rungta Institute of Pharmaceutical Sciences, India 2 Rungta Institute of Pharmaceutical Sciences and Research, India *Corresponding Author: Gyanesh Kumar Sahu, Professor and Dean, Rungta Institute of Pharmaceutical Sciences and Research, India. Research Article Received: April 14, 2023 Published: May 10, 2023 © All rights are reserved by Gyanesh Kumar Sahu., et al. Abstract Herbal vanishing cream has various advantages over existing cosmetic vanishing cream found in the market. Due to zero side effect of herbal vanishing cream, these are formulated. As every individual in today’s world need a healthy, flawless, acne free skin and naturally glowing skin hence, herbal vanishing cream are gaining popularity. The most of existing cream which has been prepared from drugs of synthetic origin, such as acyclovir, triamcinolone, calcipotriene, mometason which gives more fairness to the skin but may have various side effects such as itching or kinds of allergic reaction. The cream is oil in water emulsion. The current work is to present vanishing cream containing natural base was pleasant, effective, easily washable and completely safe for human use. In contrast with ointments, which are greasy and messy in nature and may cause staining of clothes, the prepared natural palm oil based vanishing cream was pleasant, easily washable thereby increasing patient compliance. Keywords: Vanishing Cream; Aloe Vera Introduction A cream is a semisolid formulation comprising more than 20% of water and 50% of lipid vehicles usually to apply on skin. A drug molecule is also incorporated by dissolving or dispersing it in a suitable cream base. Various sorts of creams are accessible in the market to protect the consistency of the skin. Many irritable and unpleasant substances sticking on the skin includes skin secretions, sweat, salts, sebum as well as deposits of dirt bounded by oily substances require a special process of expulsion. Hence, a vanishing cream is eminent in protecting the skin from the above substances [1]. Most of the existing vanishing creams manufactured from synthetic sources offer fairness, yet they have few side effects, for example, tingling or unfavorably allergic responses. Perhaps, creams prepared from natural and herbal sources are devoid of any above side effects [2]. Herbalism has become a center of research and focus in pharmaceutical formulation and drug discovery due to the advancements in analysis and quality along with enhanced clinical research in treating and preventing disease. According to the World Health Organization (WHO), more than 80% of people worldwide depend upon the herbal medicines and about 25% of modern drugs have been derived from plants in the USA. In India, the Ayurvedic system of medicine was derived from the inscriptions from 1500 BC. Several herbs and minerals utilized in the Ayurvedic system of medicine during the 1st millennium BC were explained by famous herbalists such as Charaka and Sushruta [3]. Vanishing cream is so termed due to their no presence or zero evidence of presence upon application and rubbing on the surface of the skin. It forms a thin imperceptible and invisible film on the skin, followed by the dissipation of water that gives non-glossy appearance [4]. DOI:10.31080/ASPS.2023.07.0954 Citation: Gyanesh Kumar Sahu., et al. “Development and Characterization of Vanishing Cream". Acta Scientific Pharmaceutical Sciences 7.6 (2023): 09-13.