Accepted Manuscript The importance of estrogen for bone protection in experimental hyperthyroidism in human osteoblasts Regiane Marques Castro Olímpio, Fernanda Cristina Fontes Moretto, Maria Teresa De Sibio, Miriane de Oliveira, Lucas Solla Mathias, Bianca Mariani Gonçalves, Igor Carvalho Deprá, Helena P. Tilli, Bruna Moretto Rodrigues, Patrícia Pinto Saraiva, Durvanei Augusto Maria, Célia Regina Nogueira PII: S0024-3205(19)30482-5 DOI: https://doi.org/10.1016/j.lfs.2019.116556 Article Number: 116556 Reference: LFS 116556 To appear in: Life Sciences Received date: 7 March 2019 Revised date: 31 May 2019 Accepted date: 9 June 2019 Please cite this article as: R.M.C. Olímpio, F.C.F. Moretto, M.T. De Sibio, et al., The importance of estrogen for bone protection in experimental hyperthyroidism in human osteoblasts, Life Sciences, https://doi.org/10.1016/j.lfs.2019.116556 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.