Key Words: Stroke, Quality Improvement, Journal Club Original Research Poster 1025860 Structural and Functional Connectivity Correlate With Motor Impairment in Chronic Supratentorial Stroke Dahyun Ahn (Veterans Health Service Medical Center, Seoul, Korea), Dae Hyun Kim Objective: To identify differences in structural and functional brain con- nectivity between post-stroke mild and severe motor impairment. Design: Retrospective cross sectional study. Setting: Twenty-four chronic stroke patients, who underwent diffusion tensor imaging and resting state functional MRI, were included. All pa- tients were classified into two groups(mild motor impairment: 11 patients; and severe motor impairment: 13 patients) according to their Fugl-Meyer motor assessment score. Participants (or Animals, Specimens, Cadavers): With randomized se- lection, we included twenty-four chronic stroke patients. Interventions: Interventions: Not applicable. Main Outcome Measure(s): tract-based spatial statistics and group- independent component analysis were applied to investigate between- groupdifferences in structural and functional connectivity, respectively. Results: The structural connectivity within motor-related brain regions was significantly increased in mild motor impairment than that in severe motor impairment (corrected P< 0.05). The intra-network functional connectivity between: 1. supplementary motor area and primary motor cortex in the affected hemisphere, 2. supplementary motor area and dorsolateral prefrontal cortex in the unaffected hemisphere and 3. ischemic lesion and primary motor cortex in the unaffected hemisphere was significantly increased in mild motor impairment than that in severe motor impairment (PFWE< 0.05). Conclusions: A better motor recovery after stroke could be facilitated by means of treatments aimed at enhancing structural and functional con- nectivity among motor related brain regions. Author(s) Disclosures: There are no financial conflicts of interest to disclose. Key Words: Stoke, Structural and Functional Brain Connectivity, Dorso- lateral Prefrontal Cortex, Primary Motor Cortex Original Research Poster 1025858 Study of Practical Energizing Alert for Blind Persons to Know The Approach Of People Akira Kimura (Gunma PAZ University) Objective: To make use of a human approach report informatization energization device in the platform environment of the simulated station and to check the upper limit speed of the walking speed of an approaching individual who the visually handicapped can avoid a collision. Design: An experimental single-arm study. Setting: General community public space. Participants (or Animals, Specimens, Cadavers): 19 blind people as a volunteer sample were requested cooperation from the Blind and Handi- capped Association in Japan. Interventions: As a placebo that the device did not work randomly, an intervention was to the device to function. Main Outcome Measure(s): The walking speed of the visually impaired and the speed of the approaching pedestrian was calculated. The time from the start of the initial approach of the approaching individual to just before the collision and the speed in the immediately preceding deceleration di- rection were obtained. Results: The trial conducted 112 trials. Under the condition that the user of the apparatus walks at approximately 0.9 m / sec, Subjects succeeded in "preparing stop” before the collision, the average speed of the approaching individuals was 1.25 m / sec, subjects failed to "stop” before the collision, the average speed of the approaching in- dividuals was 1.47 m / sec. Conclusions: The Successful speed for avoiding a collision was approxi- mately 1.25 m / sec. It would also be necessary to develop an educational method to further improve this condition and to improve practicality based on clinical adaptation range and limit. Author(s) Disclosures: This research was conducted with the Japanese government’s academic grant research (KAKENHI). There are no conflicts of interest to disclose other than that. Clinical trial registration was done before conducting the study (CTR-ID: UMIN000027880). Key Words: Vision Disorders, Assistive Technology, Electrical Equipment and Supplies. Original Research Poster 1025759 Subgroups on the Montreal Cognitive Assessment Differentiate Functional Gain In Inpatient Stroke Rehabilitation Abhishek Jaywant (Weill Cornell Medicine), Joan Toglia, Faith Gunning, Michael O’Dell Objective: To determine whether subgroups that grade cognitive severity based on the Montreal Cognitive Assessment (MoCA) are associated with functional gain during acute inpatient stroke rehabilitation. Design: Observational study of individuals with stroke admitted to acute inpatient rehabiliation. Setting: Inpatient rehabilitation facility of a large, urban academic med- ical center. Participants (or Animals, Specimens, Cadavers): NZ334 individuals with a diagnosis of stroke who underwent rehabilitation between 2012 and 2016, and who were identified prospectively and via retrospective chart review. N Z 91 individuals were excluded because they did not complete the MoCA. The included sample had a mean age of 70.3 years, mild stroke severity (mean National Institute of Health Stroke ScaleZ7.0), and were 54% male. Based on the MoCA, individuals were classified as Normal (MoCA of 25-30; NZ55), Mildly Impaired (20-24; NZ109), or Moder- ately Impaired (< 20; NZ170). Interventions: Not applicable. Main Outcome Measure(s): The motor subscale of the Functional Inde- pendence Measure (M-FIM), administered at rehabilitation admission and discharge. We calculated the mean relative functional gain (mRFG) and the mean relative functional efficiency (mRFE, which adjusts for length of stay) on the M-FIM. We also determined the proportion of individuals in each group who met the minimal clinically important difference (MCID) on the M-FIM. Results: The Moderately Impaired group had significantly poorer mRFG and mRFE than the Mildly Impaired group (mRFG mean differ- enceZ11.2, 95% CI: 4.2-18.2, pZ.001, Cohen’s dZ.45; mRFE mean differenceZ1.0, 95% CI: 0.2-1.9, pZ.013, Cohen’s dZ.36). The Mildly Impaired group in turn exhibited poorer mRFG and mRFE than the Normal group (mRFG mean differenceZ11.2, 95% CI: 4.0-18.4, pZ.02, Cohen’s dZ.57; mRFE mean differenceZ1.9, 95%CI: 0.5-3.2, pZ.004, Cohen’s dZ.55). There was a difference in M-FIM MCID by group (X2Z14.3, pZ.001). The Moderately Impaired group had the smallest proportion of individuals who made a clinically meaningful change on the M-FIM (45%), the Mildly Impaired group had an intermediate proportion (58%), and the Normal group had the highest proportion (73%). Conclusions: MoCA subgroups differentiate the degree of functional gains and the likelihood of making clinically meaningful gains in acute inpatient stroke rehabilitation. Grading cognitive impairment by MoCA subgroup can assist clinicians in predicting functional gain in stroke survivors being treated in inpatient rehabilitation, and may enable a more tailored and targeted approach to care. Author(s) Disclosures: None. www.archives-pmr.org Research Posters e125