Citation: Shah, M.A.; Udrea, A.A.;
Bondarenko, I.; Mansoor, W.;
Sánchez, R.G.; Sarosiek, T.; Bozzarelli,
S.; Schenker, M.; Gomez-Martin, C.;
Morgan, C.; et al. Evaluating
Alternative Ramucirumab Doses as a
Single Agent or with Paclitaxel in
Second-Line Treatment of Locally
Advanced or Metastatic
Gastric/Gastroesophageal Junction
Adenocarcinoma: Results from Two
Randomized, Open-Label, Phase II
Studies. Cancers 2022, 14, 1168.
https://doi.org/10.3390/
cancers14051168
Academic Editor: Kazuya Shinmura
Received: 23 December 2021
Accepted: 5 February 2022
Published: 24 February 2022
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cancers
Article
Evaluating Alternative Ramucirumab Doses as a Single Agent
or with Paclitaxel in Second-Line Treatment of Locally
Advanced or Metastatic Gastric/Gastroesophageal Junction
Adenocarcinoma: Results from Two Randomized, Open-Label,
Phase II Studies
Manish A. Shah
1,
*
,†
, Anghel Adrian Udrea
2
, Igor Bondarenko
3
, Was Mansoor
4
, Raquel Guardeño Sánchez
5
,
Tomasz Sarosiek
6
, Silvia Bozzarelli
7
, Michael Schenker
8,9
, Carlos Gomez-Martin
10
, Carys Morgan
11
,
Mustafa Özgüro ˘ glu
12
, Joanna Pikiel
13
, Haralabos P. Kalofonos
14
, Elzbieta Wojcik
15
, Tomas Buchler
16
,
Daniel Swinson
17
, Irfan Cicin
18
, Mano Joseph
19
, Ihor Vynnychenko
20
, Alexander Valerievich Luft
21
, Peter
C. Enzinger
22
, Tomas Salek
23
, Christos Papandreou
24
, Christophe Tournigand
25
, Evaristo Maiello
26
, Ran Wei
27
,
David Ferry
28
, Ling Gao
28
, Joana M. Oliveira
28
and Jaffer A. Ajani
29,†
1
Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medical College,
New York, NY 10021, USA
2
Cancer Center, Medisprof SRL, 400641 Cluj-Napoca, Romania; adrianudrea@medisprof.ro
3
Department of Oncology, Dnipropetrovsk Medical Academy, 49044 Dnipropetrovsk, Ukraine;
igor.bondarenko@rdp-ukraine.com
4
Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester M20 4BX, UK;
was.mansoor@christie.nhs.uk
5
Department of Medical Oncology, Catalan Institute of Oncology (ICO) Girona Hospital Dr Josep Trueta,
17007 Girona, Spain; rguardeno@iconcologia.net
6
Department of Clinical Oncology and Oncological Surgery, LUXMED Onkologia, 04125 Warszawa, Poland;
tomasz.sarosiek@luxmed.pl
7
Medical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital,
20089 Milan, Italy; silvia.bozzarelli@cancercenter.humanitas.it
8
Centrul de Oncologie Sf. Nectarie SRL, 200542 Craiova, Romania; michael.schenker@umfcv.ro
9
Department of Medical Oncology, University of Medicine and Pharmacy Craiova, 200342 Craiova, Romania
10
Medical Oncology Department, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain;
cgomezm@seom.org
11
Department of Clinical Oncology, Velindre Cancer Centre, Cardiff CF14 2TL, UK;
carys.morgan6@wales.nhs.uk
12
Medical Oncology, Istanbul University, Cerrahpa¸ sa, Fatih, Istanbul 34098, Turkey; mozgur@iuc.edu
13
Department of Oncology, Copernicus Podmiot Leczniczy, 80-803 Gda´ nsk, Poland; joanna.pikiel@post.pl
14
Department of Oncology, University General Hospital of Patras Rion, 26504 Patras, Greece;
kalofonos@upatras.gr
15
NZOZ Centrum Medyczne HCP, 62-030 Lubo´ n, Poland; onkologia.hcp@onet.eu
16
Department of Oncology, First Faculty of Medicine, Charles University and Thomayer University Hospital,
14059 Prague, Czech Republic; tomas.buchler@ftn.cz
17
Institute of Oncology, St James’s University Hospital, Leeds LS9 7TF, UK; daniel.swinson@nhs.net
18
Medical Oncology, Trakya University, Edirne 22030, Turkey; irfancicin@trakya.edu.tr
19
Deanesly Centre, New Cross Hospital, Wolverhamptom WV10 0QP, UK; mano.joseph@nhs.net
20
Sumy Regional Oncology Center, Sumy State University, 40000 Sumy, Ukraine;
i.vynnychenko@med.sumdu.edu.ua
21
Department of Oncology No 1 (Thoracic Surgery), Leningrad Regional Clinical Hospital,
194291 St. Petersburg, Russia; alexander_luft@mail.ru
22
Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; peter_enzinger@dfci.harvard.edu
23
Department of Clinical Oncology, Narodny Onkologicky Ustav, 83310 Bratislava, Slovakia;
tomas.salek@nou.sk
24
Department of Medical Oncology, Faculty of Medicine, University of Thessaly, Biopolis, 41223 Larissa, Greece;
cpapandr@otenet.gr
25
Department of Medical Oncology, Henri Mondor et Albert Chenevier Teaching Hospital, Assistance
Publique-Hôpitaux de Paris, University of Paris-Est Creteil, 94000 Créteil, France;
christophe.tournigand@aphp.fr
Cancers 2022, 14, 1168. https://doi.org/10.3390/cancers14051168 https://www.mdpi.com/journal/cancers