Butt SP | Volume 4; Issue 2 (2023) | Mapsci-JCCR-4(2)-081 | Review Article Citation: Butt SP, Razzaq N, Saleem Y, Cook B, Ashiq F, Kumar A, et al. Exploring Perfusion Safety: A Review of Clinical and Non- Clinical Factors with Emphasis on Quality Improvement. J Cardiol Cardiovasc Res. 2023;4(2):71-85. DOI: https://doi.org/10.37191/Mapsci-JCCR-4(2)-081 Journal of Cardiology and Cardiovascular Research Butt SP, et al., 2023-J Cardiol Cardiovasc Res ISSN:2583-259X Review Article Exploring Perfusion Safety: A Review of Clinical and Non-Clinical Factors with Emphasis on Quality Improvement Salman Pervaiz Butt 1* , Nabeel Razzaq 2 , Yasir Saleem 3 , Bill Cook 4 , Fazil Ashiq 5 , Arun Kumar 6 , Umer Darr 7 and Gopal Bhatnagar 8 Abstract This literature review examines perfusion safety in cardiothoracic surgery, with a primary focus on cardiopulmonary bypass (CPB) and circulatory devices. PRISMA guidelines were followed and various databases, including PubMed, MEDLINE, and Google Scholar, were searched using relevant keywords to identify pertinent studies and literature on the subject. The review traces the historical development of perfusion techniques and underscores the importance of equipment factors, personnel considerations, and perfusion management strategies in ensuring patient safety during CPB and circulatory device usage. Clinical aspects of perfusion safety, encompassing equipment safety features, temperature management, anticoagulation, and blood conservation, are discussed. Non-clinical aspects, including the implementation of standardized protocols, robust training structures, positive team dynamics, and the fostering of a safety-oriented culture, are also examined. Quality improvement initiatives for blood conservation, monitoring, and incident reporting are explored, along with an acknowledgment of the significant contributions of major perfusion societies and boards (AmSECT, SCPS, EBCP) in establishing standards and promoting excellence in the field. Challenges related to device design, patient selection, and perioperative management are addressed, highlighting the need for standardized practices and ongoing research to enhance perfusion safety. This comprehensive review underscores the enduring commitment to advancing perfusion safety and quality through systematic research, education, and collaborative efforts in cardiothoracic surgery. 1 Perfusionist and ECMO Specialist, Cleveland Clinic, Abu Dhabi, UAE 2 Perfusionist, Cleveland Clinic, Abu Dhabi 3 Clinical Perfusionist, AIIMS, Rishikesh, India 4 Perfusionist, Glenfield Hospital, Leicester, UK 5 MD, Cleveland Clinic, Abu Dhabi 6 MD, Cleveland Clinic Abu Dhabi 7 MD, Cleveland Clinic, Abu Dhabi 8 MD, Cleveland Clinic, Abu Dhabi * Corresponding Author: Salman Pervaiz Butt, Perfusionist and ECMO Specialist, Cleveland Clinic, Abu Dhabi, UAE. Received Date: 09-27-2023 Accepted Date: 10-06-2023 Published Date: 10-16-2023 Copyright © 2023 by Butt SP, et al. All rights reserved. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.