Annals of Ayurvedic Medicine Vol-13 Issue-1 Jan.-Mar., 2024 18 Original Research Comparative Quality Control Assessment of Different Brands of Rasayana Churna Available in Indian Market Anjali Upadhyay, Rohit Singh, Pramod Yadav, Pradeep Kumar Prajapati All India Institute of Ayurveda, New Delhi-110076. Corresponding author email : anjalirkt2527@gmail.com Received at Dec 28, 2022 || Accepted at Jan 18, 2024 Abstract Introduction: Quality assessment is imperative to establish safety and effectiveness of a drug. Rasayana Churna (RC) is a classical Ayurvedic formulation indicated in various diseases. Present study has been endeavoured to generate comparative analytical profile of different marketed brands of Rasayana Churna in India. Material & Methods: Rasayana Churna was prepared as per the method mentioned in Ayurvedic Formulary of India and marketed RC samples of GMP certified pharmacies were procured from local market in New Delhi and coded as Brand A to Brand G. all the samples were evaluated for organoleptic, physicochemical, phytochemical, HPTLC, FTIR, UV spectroscopy and PCA analysis. Results: All the samples of Rasayana Churna have shown similar organoleptic characteristics but exhibited difference in their pharmaceutical (carr’s index etc.), physicochemical, HPTLC, FTIR, UV-Vis spectroscopy and PCA profiles. Most of the quality parameters values were found in line with previously reported studies but major difference in value of quality parameters has been observed. Conclusion: The present study revealed inter sample variability in various quality control parameters. In order to limit this variability, quality certification for raw drug and adoption of uniform SOP/SMP should be made essential to ensure the quality of finished product. Apart, in order to achieve greater accuracy in findings, further quality control studies can be initiated involving different marketed samples of a drug manufactured at same point of time. Keywords: FTIR, HPTLC, Marketed samples, Rasayana Churna, Quality control. How to cite this article Upadhyay A, Singh R, Yadav P, Prajapati PK, Comparative Quality Control Assessment of Different Brands of Rasayana Churna Available in Indian Market, Annals Ayurvedic Med. 2024;13(1) 18-37, DOI. 10.5455/AAM. 134308 Introduction Ayurveda is a holistic and most ancient healthcare system providing guidelines for healthy lifestyle and cure for a wide range of diseases. In past decades, WHO is emphasizing on the quality control as well as the safety, efficacy and shelf life of the herbal formulations 1, 2 available in the market for consumer use as it has been reported that around 80 % of population in developing countries relies on traditional medicines, specifically of plant origin for their primary health care requirements 3,4 . Numerous Ayurveda classical texts comprises a plethora of single drug as well as compound formulations which are being used in the preservation of health and management of various disorders due to their broad range of activities like immuno-modulation, antioxidant etc. Rasayana Churna (RC) is one of such classical Ayurvedic formulation, which comprises dried stem of Guduchi ( Tinospora cordifolia (Willd.) Miers ex Hook.f. & Thomson.), dried fruit of Gokshura (Tribulus terrestris L.) and dried pericarp of Amalaki ( Phyllanthus emblica L.) in equal proportion and indicated in Ayurveda as Rasayana to enhance general body immunity, promote longevity and as an adaptogen 5,6 . It is also reported to have vision enhancing properties 7 . The major drawback of Ayurvedic drug industry is the scarcity of sufficient