Copyright@ Shao Wen Hung | Biomed J Sci & Tech Res| BJSTR. MS.ID.003491. 15273 Mini Review ISSN: 2574 -1241 Research and Development of Dual Functional Features of Light-Emitting Diode: Degradation of Atmospheric Fine Particulate Matter and Antimicrobial Efficacy Tzu Yun Chi 1# , Cho-Lin Li 1# , Cheng Sheng Tsung 2# , Chia Chi Chen 1 , Ying Ching Hung 1 , Chia Yu Lin 1 , Yu Wen Hung 3 , Ching Feng Chiu 4 , Chien Chao Chiu 1 , Hsuan Wen Chiu 5 , Yu Hsing Lin 6 , Wei Huang Tsai 7 , Jyh Shiun Lin 1 and Shao Wen Hung 1,6* 1 Division of Animal Industry, Animal Technology Laboratories, Agricultural Technology Research Institute, Xiangshan, Hsinchu 300, Taiwan 2 Department of Materials Science and Engineering, National Chung Hsing University, Taichung 402, Taiwan 3 Institute of Cellular and System Medicine, National Health Research Institutes, Maioli 350, Taiwan 4 Graduate Institute of Metabolism and Obesity Sciences, College of Nutrition, Taipei Medical University, Taipei 110, Taiwan 5 Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 701, Taiwan 6 Nursing Department of Yuanpei University, Xiangshan, Hsinchu 300, Taiwan 7 Department of Science and Technology, Council of Agriculture, Executive Yuan, Taipei 100, Taiwan *Corresponding author: Shao Wen Hung, Division of Animal Industry, Animal Technology Laboratories, Agricultural Technology Research Institute; Nursing Department, Xiangshan, Hsinchu 300, Taiwan DOI: 10.26717/BJSTR.2019.20.003491 Received: August 13, 2019 Published: August 20, 2019 Citation: Tzu Yun Chi, Cho Lin Li, Cheng Sheng Tsung, Chia Chi Chen, Ying Ching Hung, Chia Yu Lin, Yu Wen Hung, Ching Feng Chiu, Chien Chao Chiu, Hsuan- Wen Chiu, Yu Hsing Lin, Wei Huang Tsai, Jyh Shiun Lin, Shao Wen Hung. Research and Development of Dual Functional Features of Light-Emitting Diode: Degradation of Atmospheric Fine Particulate Matter and Antimicrobial Efficacy. Biomed J Sci & Tech Res 20(4)- 2019. BJSTR. MS.ID.003491. Keywords: Antimicrobial Efficacy; Atmospheric Fine Particulate Matter; Degradation; In vitro; Light-Emitting Diode; Staphylococcus aureus; Pseudomonas aeruginosa ARTICLE INFO Abstract Light-emitting diode (LED) is a semiconductor light source. LED in biomedical application as photodynamic therapy which induces cell death by the production of cytotoxic reactive oxygen species. Therefore, this principle of cell death can be also utilized to kill bacteria in vitro. Moreover, the R&D of the novel functional ability of LED is need as degradation of atmospheric fine particulate matter, PM 2.5 for LED industry development. Herein, we propose the use of white and blue LED devices at 450 nm wavelength as the powerful light source for in vitro killing of Staphylococcus aureus and Pseudomonas aeruginosa, and degrading atmospheric fine particulate matter, PM 2.5 . Square arranged 48-white and blue LED array was respectively designed as the light source to fit exactly 10 cm culture plate and the degradation assay of PM 2.5 was also performed. Both Staphylococcus aureus and Pseudomonas aeruginosa were order from ATCC in this study. Effects of this powerful LED devices on viability of these bacterial species and degradation assay of PM 2.5 were compared with control samples. Statistical analysis was done using Microsoft Excel Studentʼs t test. Results showed that the powerful LED devices against both Staphylococcus aureus and Pseudomonas aeruginosa was significantly effective compared to control samples in vitro. Degradation efficacy of PM 2.5 was also found after LED lighting. Taken together, the dual functional features, PM 2.5 degradation and antimicrobial efficacy, of our LED devices were demonstrated in this study. In the future, this powerful LED devices has promising applications in the human and animal life environment and in the biomedical application as disinfection, bacteriostatic, and improvement of air quality. Abbreviations: LED: Light-Emitting Diode; MRSA: Methicillin-Resistant Staphylococcus Aureus; PA: Pseudomonas Aeruginosa; ROS: Reactive Oxygen Species; PDI: Photodynamic Inactivation; UV: Ultraviolet