Abstracts S249 P.349 Fibrinogen, C-reactive protein and hs-C reactive protein as putative biological markers for depression or anxiety in an old outpatients population R. Grigoras 1,∗ , T. Purnichi 2 , M. Grigoras 3 , A.N. Pavel 4 , V.P. Matei 4 1 Voila Psychiatric Hospital, 1st department, Campina, Ro- mania 2 "Ana Aslan" National Institute of Gerontology and Geri- atrics, Psychiatry, Bucharest, Romania 3 University Emergency Hospital Bucharest, Orthopedics and traumatology, Bucharest, Romania 4 University of Medicine and Pharmacy “Carol Davila”, Psy- chiatry, Bucharest, Romania Background: Increased life expectancy worldwide led to a concurrent increase in physical or psychological disabilities in the very old age population [1]. The aim of this study was to identify biological markers associated with depression and anxiety in elderly patients over 75 years old. Literature data research suggested con- troversial results regarding positive associations between inflammatory markers and depressive symptoms [2,3] or anxiety [4] in very old age population. Methods: Data analysed in our paper refers to the elderly patients (age≥ 75; N=29) included in a prospective study with N=100 patients who presented for routine laboratory evaluations between 1st February-30th June 2016 in the outpatient clinic of the National Institute of Gerontology and Geriatrics “Ana Aslan”, Bucharest, Romania. For all the participants, socio-demographic information was collected and included: gender, age, marital status, environmen- tal origin, level of education, socio-economic status. Data about somatic comorbidities were also recorded. Depres- sive and anxiety symptoms were evaluated using the Hos- pital Anxiety and Depression Scale (HADS). Laboratory data included the serum fibrinogen, C-reactive protein (CRP) and high sensitivity-C reactive protein (hs-CRP) determination for all the patients. This study was approved by the ethi- cal committee of the University of Medicine and Pharmacy of Craiova, Romania. Details of the study were explained to the patients and a written consent was obtained from all participants. We used the recommended cut-off of ≥ 8 points to identify the cases of elevated levels of depressive symptoms with the HADS-D and anxiety symptoms with the HADS-A subscales. Statistical Package for Social Sciences version 22 was used to analyse the data, specifically: descriptive data, t- test(data for fibrinogen was normally distributed therefore we used t-test), Mann Whitney U (data for CRP and hs-CRP was abnormally distributed therefore we used Mann Whit- ney U). Results: From the total number of patients, 58.6% (N=17) were female, with a mean age of 79.79 (±4.89) years, range 75-96 years, from the urban area 89.7% (N= 26), retired 100% (N=29). All the patients presented somaticcomorbidi- ties. Of them, N=17 (58.6%) presented anxiety and N= 21 (72.4%) depressive symptoms. There were no differences between groups (depression vs control, anxiety vs. control) regarding socio-economic status, age, sex, or somatic co- morbidities (data not presented). We didn’t find any statistically significant differences be- tween patients presenting symptoms of anxiety (M=314.5; SD=64.1) and those without (M=324.42; SD=42.6) regarding fibrinogen plasma levels, p=.657. As for patients presenting depressive symptoms (M=311.1; SD=60.8) and those with- out (M=338.3; SD=44.9), no statistically significant differ- ences in fibrinogen plasma levels were found either, p=.261. Mann Whitney U test did not show any statistical differences for CRP and hs-CRP plasma levels in patients with symptoms of anxiety (U=99.5, p=.896; U=86, p=.479) or depression (U=75, p=.604; U=70, p=.495). Conclusions: We did not find any statistically significant as- sociation between elevated plasma levels of fibrinogen, CRP and hs-CRP in elderly patients over 75 years old and anxiety or depressive symptoms. As increased inflammatory activ- ity accompanies ageing and also many chronic disorders of the elderly, an important limitation of studying inflamma- tory markers at this age is represented by great comorbidi- ties with physical illnesses. References [1] Laks, J., Engelhardt, E., 2010. Peculiarities of geriatric psychi- atry: A focus on aging and depression. CNS Neurosci. Ther. 16, 374–379 2010. [2] Penninx, B.W., Kritchevsky, S.B., Yaffe, K., et al., 2003. Inflam- matory markers and depressed mood in older persons: results from the Health, Aging and Body Composition study. Biol. Psy- chiatry 54, 566–572. [3] Kop, W.J., Gottdiener, J.S., Tangen, C.M., et al., 2002. Inflam- mation and coagulation factors in persons >65 years of age with symptoms of depression but without evidence of myocardial is- chemia. Am. J. Cardiol. 89, 419–424. [4] Baune, B.T., Smith, E., Reppermund, S., et al., 2012. Inflamma- tory biomarkers predict depressive, but not anxiety symptoms during aging: the prospective Sydney Memory and Aging Study. Psychoneuroendocrinology 37 (9), 1521–1530. doi: 10.1016/j.euroneuro.2019.09.367 P.350 Electroconvulsive therapy in elderly people: Age should not be a limiting factor in our daily practice L. Martinez Fernandez 1,∗ , C. Massaneda 1 , A. De Arriba Arnau 1,2 , N. Salvat-Pujol 1,2 , V. Soria 1,2,3 , J.M. Menchón 1,2,3 , M. Urretavizcaya 1,2,3 1 Institut Català de la Salut ICS- Bellvitge University Hos- pital, Psychiatry Department, L’Hospitalet de Llobregat, Spain 2 Bellvitge Biomedical Research Institute IDIBELL Neuro- sciences Group-Psychiatry and Mental Health- Mood Disor- ders Clinical and Research Unit- Bellvitge University Hos- pital, Psychiatry Department, L’Hospitalet de Llobregat, Spain 3 University of Barcelona UB, Centro de Investigación Biomédica en Red de Salud Mental-CIBERSAM G17, Barcelona, Spain