_____________________________________________________________________________________________________ *Corresponding author: E-mail: talk2vu@gmail.com; Asian Journal of Research in Animal and Veterinary Sciences 5(3): 19-25, 2020; Article no.AJRAVS.56198 In vitro Studies on the Effect of Parasitosis on Amino Acid Profile of Bulinus species Victor Ugochuchwu Obisike 1* , Godwin Nyiutaha Imande 2 and Elizabeth U. Amuta 2 1 Department of Animal and Environmental Biology, Abia State University, Uturu, Abia State, Nigeria. 2 Department of Zoology, Federal University of Agriculture Makurdi, Benue State, Nigeria. Authors’ contributions This work was carried out in collaboration among all authors. Authors VUO and GNI designed the study. Author VUO performed the statistical analysis, wrote the protocol and wrote the first draft of the manuscript. Authors VUO, GNI and EUA managed the analyses of the study. Author VUO managed the literature searches. All authors read and approved the final manuscript. Article Information Editor(s): (1) Dr. Fabio da Costa Henry, State University of Northern of Rio de Janeiro, UENF, Brazil. Reviewers: (1) Ana Júlia Pinto Fonseca Sieuve Afonso, Universidade Nova de Lisboa, Instituto de Higiene e Medicina Tropical, Portugal. (2) Opeyemi Gbenga Oso, University of Ibadan, Nigeria. (3) Mahmud Ali Umar, Kano State University of Technology, Nigeria. Complete Peer review History: http://www.sdiarticle4.com/review-history/56198 Received 15 February 2020 Accepted 22 April 2020 Published 27 April 2020 ABSTRACT Freshwater snails are intermediate hosts of some trematode diseases including Schistosomiasis. This study was designed to study the interactions between Bulinus species and the larval stages of Schistosoma haematobium specifically the amino acid levels of the infected freshwater snails. Bulinus species were collected from their natural habitats, reared in the laboratory, and exposed to the larval stage of Schistosoma haematobium. Using the method described in Association of Official Analytical Chemists in determining Amino acid profile the amino acid profile of both the infected and non-infected Bulinus species was determined. Histidine, valine, methionine, phenylalanine, lysine levels of the Bulinus species decreased amongst the infected starved snails than in the control. The amino acids profile decreased significantly across the different challenges that the snails Bulinus were exposed to. This study has opened research windows for the control of urinary schistosomiasis through the control of the intermediate hosts using some biochemical approach. Original Research Article