Research Article This work is licensed under a CC BY 4.0 License International Research Journal of Ayurveda & Yoga Vol. 6 (2),01-10, Feb,2023 ISSN: 2581-785X : https://irjay.com/ DOI: 10.47223/IRJAY.2023.6201 Pharmaceutical Analytical Study of Yashada Bhasma through Sem & Edx Veda SM 1 , Surekha S Medikeri 2 , Vidya Sagar GV 3 1. PG Scholar, Dept. of PG studies Rasashastra & Bhaishajya Kalpana, G.A.M.C. Bengaluru. 2. Professor & H.O.D., Dept. of Rasashastra & Bhaishajya Kalpana, G.A.M.C. Bengaluru. 3. Associate Professor, Dept. of Biochemistry, KIMS, Bengaluru INTRODUCTION In the present scenario there have been findings that have shown Ayurveda is a highly scientific and perfect life science; in the meanwhile there are also reports of toxicity related to the bhasmas in recent literatures 1 . So the scientific evidence based research is necessary which can be achieved by multidisciplinary manner so that it helps in establishing the facts which reaches everywhere, so that acceptance of Ayurveda medicines is achieved globally. Yashada is a metal (dhatu) 2 , comes under pootilohas group like Naga (Pb), Vanga (Sn), Yashada (Zn). These metals which have low melting points when compared to other metals in Ayurveda and burns with characteristic odor. It is widely used in chronic & acute diseases like diabetes, eye disorders and urinary diseases etc 3 . As the metals are the inorganic compounds which cannot be absorbed by the human body, hence there is need of transformation of inorganic metals (nireendriya) in to organo metallic form (sendriya) which is the absorbable form for human body. This is achieved by the bhasmeekarana (incineration). The ayurvedic bhasmas are non-toxic because during the process of bhasmeekarana its toxicity will be reduced by different liquid media used in samanyashodhana process 4 . To enhance the required property in the drug particular liquid media is opted for visheshashodhana. Yashadabhasma is a zinc based herbo metallic compound which is prepared from Zn metal and other herbal media drugs via purification, roasting and incineration. To prove its proper formation it is tested with the modern techniques like the SEM, EDAX, XRD etc, which provides authenticated proof for the traditional Article Info Article history: Received on: 06-01-2023 Accepted on: 15-02-2023 Available online: 28-02-2023 Corresponding author- Vidya Sagar GV, Associate Professor, Dept. of Biochemistry, KIMS, Bengaluru Email: vedasosale@gmail.com ABSTRACT: Yashada is a dhatu (metal) comes under pootiloha (metals with low melting point and burns with characteristic odor) its usage in bhasma (fine particles) form is prominently seen in the diseases like Prameha (Diabetes) Netrarogas (eye diseases) Vrana (wound) Kushta (skin diseases) etc. Raw Yashada (Metallic ore) was subjected to samanyashodhana (common purification process for metals), Visheshashodhana (special purification), Jarana (intermittent process of calcinations for pootilohas), Marana (incineration) followed by bhasmaparekshas (tests for proper calx) were done as mentioned in classical texts of Rasashastra and in each stage the product was subjected to SEM (Scanning Electron microscopy) & EDX (Energy dispersive X- Ray) studies. Results showed Yashada bhasma was predominantly Zinc oxide with particle size reduction to about nano particle size and making the bhasma more bio-absorbable. Key words: Yashada, bhasma, Zinc, SEM and EDAX.