Research Article Comparative Evaluation of Efficacy and Safety of the Diode Laser (980 nm) and Sclerotherapy for the Treatment of Oral Pyogenic Granuloma Peeyush Shivhare , 1 Naqoosh Haidry , 1 Neha Sah , 2 Ajay Kumar , 3 Abhishek Gupta , 4 Ankur singh , 5 Mohan Raju Penumatcha , 6 and Shalini Subramanyam 7 1 Department of Dentistry, All India Institute of Medical Sciences, Patna 801507, India 2 Department of Oral and Maxillofacial Surgery, Dental College Azamgarh, Azamgarh 276128, India 3 Department of Oral Medicine and Radiology, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India 4 Department of Oral Medicine and Radiology, Chitwan Medical College, Bharatpur, Chitwan 44207, Nepal 5 Department of Oral Medicine and Radiology, Narsinhbhai Patel Dental College and Hospital, Visnagar 384315, India 6 Private Dental Clinic, Secunderabad 500003, India 7 Private Dental Clinic, Bangalore 560038, India Correspondence should be addressed to Abhishek Gupta; gupta.abhishek@cmc.edu.np Received 15 July 2022; Revised 30 August 2022; Accepted 5 September 2022; Published 17 September 2022 Academic Editor: Giuseppe Minervini Copyright © 2022 Peeyush Shivhare et al. is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Pyogenic granuloma (PG) is a tumor-like, non-neoplastic lesion of the soft tissue that commonly appears in the oral cavity. Various treatment modalities have been discussed, including surgical excision, cryosurgery, curettage, electrodessication, corticosteroid injection, sclerotherapy, and lasers. is observational retrospective study compared effectiveness between diode lasers and sclerotherapy for PG treatment. Materials and Methods. From July 2016 to January 2021, data of oral PG cases treated with sclerotherapy and diode lasers were gathered. Patients were evaluated and categorized according to their gender, sex, site of lesions, size of lesions, number of sessions, details of side effects, details of the VAS (Visual Analogue Scale) on third postoperative day, response of treatment to individual groups, time required for complete resolution, and details of recurrence. Inferential statistical analysis was performed. Results. We included 73 patients, of whom 43 and 30 received laser and sclerotherapy treatment, respectively. Compared with the sclerotherapy group, the laser group had less side effects including pain, edema, ulceration, ecchymosis, infections, and scarring. e difference in postoperative pain (VAS scale) between the groups was statistically significant (p-value 0.004). Complete remission was seen in the laser group, while 3 cases of the sclerotherapy group had no response (p-value -0.034). e laser group experienced greater recurrence than did the sclerotherapy group. Conclusions. Both sclerotherapy with laser and 3% sodium tetradecyl sulfate are effective for treating oral PG. Sclerotherapy is more effective in preventing recurrence. In terms of side effects, diode lasers are superior to sclerotherapy. 1. Introduction Pyogenic granuloma (PG) is a tumor-like, non-neoplastic lesion of the soft tissue that commonly appears in the oral cavity. PG is not a granuloma but reactive inflammatory hyperplasia. is term itself is inaccurate because this entity does not contain any purulent material and histologically resembles a granuloma. [1] Various terminologies have been proposed, such as Crocker and Hartzell’s disease, angiog- ranuloma, vascular epulis, pregnancy tumor, granuloma gravidarum, hemangiomatous granuloma, and granuloma telangiectacticum. Several studies have classified PG as a lobar capillary hemangioma from a histological standpoint [2, 3]. Hindawi International Journal of Dentistry Volume 2022, Article ID 8269221, 8 pages https://doi.org/10.1155/2022/8269221