_____________________________________________________________________________________________________ *Corresponding author: E-mail: alex.ogregadeie@gmail.com; International Journal of Advances in Nephrology Research 3(1): 26-36, 2020; Article no.IJANR.61499 Evaluation of Antioxidant and Nephroprotective Effects of Hypoestes rosea in Acetaminophen Induced-Toxicity in Albino Rats Ogregade, I. E. 1* , Igwe, F. 2 and Davies, T. G. 1 and Bartimaeus, E. S. 1 1 Department of Medical Laboratory Science, Rivers State University, Port Harcourt, Nigeria. 2 Department of Biochemistry, Rivers State University, Port Harcourt, Nigeria. Authors’ contributions This work was carried out in collaboration among all authors. Author ESB designed the study. Author FI wrote the protocol. Author TGD wrote the first draft of the manuscript and author IEO managed the analyses of the study and the literature searches. All authors read and approved the final manuscript. Article Information Editor(s): (1) Dr. Darko Nozic, Military Medical Academy, Serbia. Reviewers: (1) Pratishtha Sharma, Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan, India. (2) Mahesh Bhanudas Narkhede, Dr. Rajendra Gode College of Pharmacy, India. (3) Kumaraswamy Gandla, Care College of Pharmacy-Warangal, Telanngana, India. Complete Peer review History: http://www.sdiarticle4.com/review-history/61499 Received 15 July 2020 Accepted 21 September 2020 Published 01 October 2020 ABSTRACT Aim: The aim of this study was to evaluate antioxidant and nephroprotective effects of Hypoestes rosea in acetaminophen induced-toxicity in albino rats. Study Design: This study is a case-controlled interventional study. Place and Duration of Study: This study was conducted at the Experimental Animal Unit of the Department of Human Physiology, University of Port- Harcourt, between June 2018 and December, 2019. Methodology: A total of 112 adult apparently healthy albino rats weighing (180-220g) were used for this study. The rats were divided into six experimental groups of extract control (EC), negative control (NC), positive control (PC), aqueous extract of Hypoestes rosea (AEHr)100 mg/kg body weight (b w), AEHr 200 mg/kg b w., and AEHr 300 mg/kg b w. groups each of six rats. At the end of the study period, blood samples were taken through the jugular vein under chloroform anaesthesia for oxidative stress markers (SOD & TAC) and renal function parameters (K+, Na+, Cl - , HCO 3, urea & creatinine), analyzed using auto analyzers and spectrophotometric methods. Kidney of rats were also harvested for histopathological study. Original Research Article