Int.J.Curr.Microbiol.App.Sci (2019) 8(7): 2656-2660 2656 Original Research Article https://doi.org/10.20546/ijcmas.2019.807.327 COPD and Intestinal Dysbiosis R.S. Bayramova*, M.S. Novruzova, H.M. Aliyeva and J.X. Talibova Azerbaijan Medical University, Department of Medical Microbiology and Immunology, Azerbaijan *Corresponding author ABSTRACT Introduction Today, chronic obstructive pulmonary disease (COPD) is the most common disease of the bronchopulmonary system, leading to a decrease in the quality of life of patients and is characterized by frequent infectious-related exacerbations. Every new exacerbation not only increases the risk of reducing respiratory function, but also causes a higher incidence of antibiotic therapy (1, 2) By WHO forecasts, a further increase in the prevalence and mortality of COPD among people of working age is predicted, due to uncontrolled environmental pollution, a tobacco pandemic, an increase in the level of allergens and a genetic predisposition (3, 4, 5, 6). In terms of environmental and social disadvantage in patients with COPD, the immune system is inhibited, leading to the formation of secondary immunodeficiency and transformation of acute respiratory system diseases into a protracted chronic form (7.8) When chronization and progression of COPD, there is a violation of cellular and humoral immunity, production of pro-inflammatory International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 8 Number 07 (2019) Journal homepage: http://www.ijcmas.com By WHO forecasts, a further increase in the prevalence and mortality of COPD among people of working age is predicted, due to uncontrolled environmental pollution, a tobacco pandemic, an increase in the level of allergens and a genetic predisposition. In chronization and progression of COPD, there is a violation of cellular and humoral immunity, production of pro-inflammatory cytokines of phagocytic cell activity that contribute to the persistence of the inflammatory process in the lungs. Therefore, the study of the state of intestinal microflora in patients with COPD and the timely correction of impaired microbiocinosis is an important task that needs to be studied. Patients with COPD have a chronic inflammatory process in the bronchopulmonary system, accompanied by inhibition of the functional activity of neutrophils, which complicates the formation of humoral immunity and leads to a persistent course of the disease with frequent exacerbations. The revealed violations of COPD associated with intestinal dysbacteriosis indicate pronounced manifestations of secondary immunodeficiency. The obtained data allow us to recommend bacteriological and immunological examination of patients with COPD to identify immunological deficiencies with concomitant intestinal dysbiosis for the purpose of complex treatment with the use of immunocorrecting and probiotics. Keywords Chronic obstructive pulmonary, Secondary immunodeficiency, Inflammatory process, Chronization, Phagitosis activity, Normal intestinal microflora, Dysbiotic changes, Bifidus bacteria and lactobacilli, E.coli Accepted: 20 June 2019 Available Online: 10 July 2019 Article Info