www.mnf-journal.com Page 1 Molecular Nutrition & Food Research Received: 07-Dec-2016; Revised: 13-Jul-2017; Accepted: 14-Jul-2017 This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/mnfr.201601066. This article is protected by copyright. All rights reserved. Immunomodulatory properties of Olea europaea leaf extract in intestinal inflammation Teresa Vezza 1 , Francesca Algieri 1 , Alba Rodríguez-Nogales 1 , José Garrido-Mesa 1 , M Pilar Utrilla 1 , Nassima Talhaoui 2,3 , Ana María Gómez-Caravaca 2,3 , Antonio Segura-Carretero 2,3 , M Elena Rodríguez-Cabezas 1 , Giovanni Monteleone 4 , Julio Gálvez 1 1 CIBER-EHD, Department of Pharmacology, ibs.GRANADA, Center for Biomedical Research (CIBM), University of Granada, Granada, Spain. 2 Department of Analytical Chemistry, University of Granada. Avda. Fuentenueva s/n, 18071 Granada, Spain. 3 Research and Development of Functional Food Centre (CIDAF), PTS Granada, Avda.del Conocimiento s/n., Edificio Bioregión, 18016 Granada, Spain. 4 Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy. Abbreviations: CD, Crohn’s disease; COX-2, cyclooxygenase-2; DAI, disease activity index; DNBS, dinitrobenzenesulfonic acid; DSS, dextran sulfate sodium; ICAM-1, intercellular adhesion molecule-1; IBD, inflammatory bowel disease; iNOS, inducible nitric oxide synthase; MIP-2, macrophage inflammatory protein-2; MUC-2, mucin-2; NO, nitric oxide; OLE, olive leaf extract; PBMCs, peripheral blood mononuclear cells; TFF, trefoil factor; TNF, tumor necrosis factor; ZO, zonula occludens