Robust prediction of resistance to trimethoprim in 1 Staphylococcus aureus 2 Philip W. Fowler ⇤1 , Kevin Cole 2 , N. Claire Gordon 1 , Angela M Kearns 3 , Martin J. Llewelyn 2 , 3 Tim E. A. Peto 1 , Derrick W. Crook 1 , and A. Sarah Walker † 1 4 1 Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Headley Way, 5 Oxford, OX3 9DU, United Kingdom 6 2 Department of Infectious Diseases and Microbiology, Royal Sussex County Hospital, Brighton, 7 Brighton and Sussex Medical School, BN1 9PS, United Kingdom 8 3 Antimicrobial Resistance and Healthcare Associated Infections Reference Unit, Public Health 9 England, Colindale, NW9 5EQ, United Kingdom 10 October 24, 2017 11 KEYWORDS: clinical microbiology, antibiotic susceptibility testing, free energy calculations, 12 antimicrobial resistance 13 ⇤ Lead and Corresponding author. Email: philip.fowler@ndm.ox.ac.uk, Twitter: @philipwfowler † MJL, TEAP, DWC and ASW are all Senior Authors 1